CRISP1 protein (Homo sapiens) - STRING network view

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CRISP1

cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation (249 aa)

Predicted Functional Partners:

GPX5

0.667

ADAM7

0.592

ALDH6A1

0.577

EPPIN

0.565

NPC2

0.545

SPAM1

0.532

CD52

0.517

MTDH

0.517

GPR64

0.510

TEDDM1

0.506

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM7	CRISP1	ENSP00000175238	ENSP00000338276	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	0.592
ADAM7	EPPIN	ENSP00000175238	ENSP00000452085	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility	0.450
ADAM7	GPR64	ENSP00000175238	ENSP00000369198	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	G protein-coupled receptor 64	0.415
ADAM7	GPX5	ENSP00000175238	ENSP00000392398	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	glutathione peroxidase 5 (epididymal androgen-related protein); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids	0.584
ADAM7	NPC2	ENSP00000175238	ENSP00000451112	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...]	0.400
ADAM7	SPAM1	ENSP00000175238	ENSP00000345849	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid	0.475
ALDH6A1	CRISP1	ENSP00000450436	ENSP00000338276	aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	0.577
CD52	CRISP1	ENSP00000363330	ENSP00000338276	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	0.517
CD52	GPR64	ENSP00000363330	ENSP00000369198	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	G protein-coupled receptor 64	0.520
CD52	GPX5	ENSP00000363330	ENSP00000392398	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	glutathione peroxidase 5 (epididymal androgen-related protein); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids	0.467
CD52	NPC2	ENSP00000363330	ENSP00000451112	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	Niemann-Pick disease, type C2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...]	0.582
CD52	SPAM1	ENSP00000363330	ENSP00000345849	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid	0.416
CD52	TEDDM1	ENSP00000363330	ENSP00000356536	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	transmembrane epididymal protein 1	0.472
CRISP1	ADAM7	ENSP00000338276	ENSP00000175238	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	ADAM metallopeptidase domain 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein (By similarity)	0.592
CRISP1	ALDH6A1	ENSP00000338276	ENSP00000450436	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA	0.577
CRISP1	CD52	ENSP00000338276	ENSP00000363330	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role	0.517
CRISP1	EPPIN	ENSP00000338276	ENSP00000452085	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	epididymal peptidase inhibitor; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility	0.565
CRISP1	GPR64	ENSP00000338276	ENSP00000369198	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	G protein-coupled receptor 64	0.510
CRISP1	GPX5	ENSP00000338276	ENSP00000392398	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	glutathione peroxidase 5 (epididymal androgen-related protein); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids	0.667
CRISP1	MTDH	ENSP00000338276	ENSP00000338235	cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation	metadherin; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance	0.517

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