node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNTL | BHLHE40 | ENSP00000374357 | ENSP00000256495 | aryl hydrocarbon receptor nuclear translocator-like | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | 0.989 |
ARNTL | BHLHE41 | ENSP00000374357 | ENSP00000242728 | aryl hydrocarbon receptor nuclear translocator-like | basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription | 0.976 |
ARNTL | CRY1 | ENSP00000374357 | ENSP00000008527 | aryl hydrocarbon receptor nuclear translocator-like | cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL | 0.999 |
ARNTL | CRY2 | ENSP00000374357 | ENSP00000406751 | aryl hydrocarbon receptor nuclear translocator-like | cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL | 0.999 |
ARNTL | CSNK1E | ENSP00000374357 | ENSP00000352929 | aryl hydrocarbon receptor nuclear translocator-like | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation | 0.999 |
ARNTL | EP300 | ENSP00000374357 | ENSP00000263253 | aryl hydrocarbon receptor nuclear translocator-like | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | 0.978 |
ARNTL | NPAS2 | ENSP00000374357 | ENSP00000338283 | aryl hydrocarbon receptor nuclear translocator-like | neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity) | 0.998 |
ARNTL | NR1D1 | ENSP00000374357 | ENSP00000246672 | aryl hydrocarbon receptor nuclear translocator-like | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.994 |
ARNTL | RORA | ENSP00000374357 | ENSP00000261523 | aryl hydrocarbon receptor nuclear translocator-like | RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5’-[AT][TA]A[AT][CGT]TAGGTCA-3’. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] | 0.973 |
ARNTL | TIMELESS | ENSP00000374357 | ENSP00000450607 | aryl hydrocarbon receptor nuclear translocator-like | timeless homolog (Drosophila); Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules | 0.986 |
BHLHE40 | ARNTL | ENSP00000256495 | ENSP00000374357 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | aryl hydrocarbon receptor nuclear translocator-like | 0.989 |
BHLHE40 | BHLHE41 | ENSP00000256495 | ENSP00000242728 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription | 0.851 |
BHLHE40 | CRY1 | ENSP00000256495 | ENSP00000008527 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL | 0.789 |
BHLHE40 | CRY2 | ENSP00000256495 | ENSP00000406751 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL | 0.598 |
BHLHE40 | EP300 | ENSP00000256495 | ENSP00000263253 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | 0.404 |
BHLHE40 | NPAS2 | ENSP00000256495 | ENSP00000338283 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity) | 0.988 |
BHLHE40 | NR1D1 | ENSP00000256495 | ENSP00000246672 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.760 |
BHLHE40 | RORA | ENSP00000256495 | ENSP00000261523 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5’-[AT][TA]A[AT][CGT]TAGGTCA-3’. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one [...] | 0.749 |
BHLHE40 | TIMELESS | ENSP00000256495 | ENSP00000450607 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | timeless homolog (Drosophila); Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules | 0.511 |
BHLHE41 | ARNTL | ENSP00000242728 | ENSP00000374357 | basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses both basal and activated transcription | aryl hydrocarbon receptor nuclear translocator-like | 0.976 |