node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FANK1 | GZF1 | ENSP00000357682 | ENSP00000338290 | fibronectin type III and ankyrin repeat domains 1 | GDNF-inducible zinc finger protein 1 | 0.651 |
GZF1 | FANK1 | ENSP00000338290 | ENSP00000357682 | GDNF-inducible zinc finger protein 1 | fibronectin type III and ankyrin repeat domains 1 | 0.651 |
GZF1 | HOXA10 | ENSP00000338290 | ENSP00000283921 | GDNF-inducible zinc finger protein 1 | homeobox A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5’-AA[AT]TTTTATTAC-3’ | 0.813 |
GZF1 | KDM2A | ENSP00000338290 | ENSP00000432786 | GDNF-inducible zinc finger protein 1 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
GZF1 | LRRC66 | ENSP00000338290 | ENSP00000341944 | GDNF-inducible zinc finger protein 1 | leucine rich repeat containing 66 | 0.592 |
GZF1 | NCL | ENSP00000338290 | ENSP00000318195 | GDNF-inducible zinc finger protein 1 | nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-stranded DNA 5’-TTAGGG-3’ repeats | 0.586 |
GZF1 | NFATC1 | ENSP00000338290 | ENSP00000327850 | GDNF-inducible zinc finger protein 1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells | 0.564 |
GZF1 | NPM1 | ENSP00000338290 | ENSP00000296930 | GDNF-inducible zinc finger protein 1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.564 |
GZF1 | XRN1 | ENSP00000338290 | ENSP00000264951 | GDNF-inducible zinc finger protein 1 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.543 |
GZF1 | YBX1 | ENSP00000338290 | ENSP00000361626 | GDNF-inducible zinc finger protein 1 | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.564 |
GZF1 | ZSCAN18 | ENSP00000338290 | ENSP00000470123 | GDNF-inducible zinc finger protein 1 | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.524 |
HOXA10 | GZF1 | ENSP00000283921 | ENSP00000338290 | homeobox A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5’-AA[AT]TTTTATTAC-3’ | GDNF-inducible zinc finger protein 1 | 0.813 |
KDM2A | GZF1 | ENSP00000432786 | ENSP00000338290 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | GDNF-inducible zinc finger protein 1 | 0.501 |
KDM2A | ZSCAN18 | ENSP00000432786 | ENSP00000470123 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.501 |
LRRC66 | GZF1 | ENSP00000341944 | ENSP00000338290 | leucine rich repeat containing 66 | GDNF-inducible zinc finger protein 1 | 0.592 |
LRRC66 | ZSCAN18 | ENSP00000341944 | ENSP00000470123 | leucine rich repeat containing 66 | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.704 |
NCL | GZF1 | ENSP00000318195 | ENSP00000338290 | nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-stranded DNA 5’-TTAGGG-3’ repeats | GDNF-inducible zinc finger protein 1 | 0.586 |
NCL | NPM1 | ENSP00000318195 | ENSP00000296930 | nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-stranded DNA 5’-TTAGGG-3’ repeats | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.999 |
NCL | YBX1 | ENSP00000318195 | ENSP00000361626 | nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-stranded DNA 5’-TTAGGG-3’ repeats | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.580 |
NFATC1 | GZF1 | ENSP00000327850 | ENSP00000338290 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells | GDNF-inducible zinc finger protein 1 | 0.564 |