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ERC2 ERC2 NLGN1 NLGN1 ERC1 ERC1 NLGN3 NLGN3 NRXN3 NRXN3 EPB41L3 EPB41L3 NOVA1 NOVA1 NLGN2 NLGN2 FOXQ1 FOXQ1 EPB41L1 EPB41L1 NLGN4X NLGN4X
"NRXN3" - neurexin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
NRXN3neurexin 3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity) (1061 aa)    
Predicted Functional Partners:
NLGN2
neuroligin 2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] (835 aa)
        score_image   score_image   0.954
NLGN1
neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) (823 aa)
        score_image   score_image   0.899
NLGN3
neuroligin 3 (848 aa)
        score_image   score_image   0.886
FOXQ1
forkhead box Q1; Plays a role in hair follicle differentiation (By similarity) (403 aa)
            score_image   0.815
ERC1
ELKS/RAB6-interacting/CAST family member 1 (1116 aa)
            score_image   0.795
NLGN4X
neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions (816 aa)
            score_image   0.789
EPB41L1
erythrocyte membrane protein band 4.1-like 1 (881 aa)
            score_image   0.763
NOVA1
neuro-oncological ventral antigen 1; May regulate RNA splicing or metabolism in a specific subset of developing neurons (507 aa)
            score_image   0.750
ERC2
ELKS/RAB6-interacting/CAST family member 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ (957 aa)
            score_image   0.749
EPB41L3
erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas (1087 aa)
            score_image   0.747
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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