node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | BTD | ENSP00000344789 | ENSP00000306477 | acetyl-CoA carboxylase alpha | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.645 |
ACACA | HLCS | ENSP00000344789 | ENSP00000338387 | acetyl-CoA carboxylase alpha | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | 0.995 |
ACACA | MCCC1 | ENSP00000344789 | ENSP00000265594 | acetyl-CoA carboxylase alpha | methylcrotonoyl-CoA carboxylase 1 (alpha) | 0.841 |
ACACA | OXSM | ENSP00000344789 | ENSP00000280701 | acetyl-CoA carboxylase alpha | 3-oxoacyl-ACP synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function | 0.974 |
ACACA | PC | ENSP00000344789 | ENSP00000377527 | acetyl-CoA carboxylase alpha | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.638 |
ACACA | PCCA | ENSP00000344789 | ENSP00000365462 | acetyl-CoA carboxylase alpha | propionyl CoA carboxylase, alpha polypeptide | 0.839 |
ACACA | PCCB | ENSP00000344789 | ENSP00000419027 | acetyl-CoA carboxylase alpha | propionyl CoA carboxylase, beta polypeptide | 0.758 |
ACACA | SLC5A6 | ENSP00000344789 | ENSP00000310208 | acetyl-CoA carboxylase alpha | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.951 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | BTD | ENSP00000341044 | ENSP00000306477 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.472 |
ACACB | HLCS | ENSP00000341044 | ENSP00000338387 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | 0.997 |
ACACB | MCCC1 | ENSP00000341044 | ENSP00000265594 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | methylcrotonoyl-CoA carboxylase 1 (alpha) | 0.824 |
ACACB | OXSM | ENSP00000341044 | ENSP00000280701 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 3-oxoacyl-ACP synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function | 0.972 |
ACACB | PC | ENSP00000341044 | ENSP00000377527 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.634 |
ACACB | PCCA | ENSP00000341044 | ENSP00000365462 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | propionyl CoA carboxylase, alpha polypeptide | 0.826 |
ACACB | PCCB | ENSP00000341044 | ENSP00000419027 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | propionyl CoA carboxylase, beta polypeptide | 0.768 |
ACACB | SLC5A6 | ENSP00000341044 | ENSP00000310208 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.955 |
BTD | ACACA | ENSP00000306477 | ENSP00000344789 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | acetyl-CoA carboxylase alpha | 0.645 |
BTD | ACACB | ENSP00000306477 | ENSP00000341044 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.472 |