Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MRPL35 | mitochondrial ribosomal protein L35 (188 aa) | ||||||||||||
Predicted Functional Partners:
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 | MRPL54 | mitochondrial ribosomal protein L54 (138 aa) |
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0.569 | |||||||||
 | RTN4IP1 | reticulon 4 interacting protein 1; Appears to be a potent inhibitor of regeneration following spinal cord injury (396 aa) |
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0.548 | ||||||||||
 | ENSG00000255730 | Uncharacterized protein (479 aa) |
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0.543 | ||||||||||
 | UQCRH | ubiquinol-cytochrome c reductase hinge protein; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (91 aa) |
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0.503 | |||||||||
 | BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components- branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (445 aa) |
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0.488 | ||||||||||
 | TSPAN6 | tetraspanin 6 (245 aa) |
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0.462 | ||||||||||
 | MRPL32 | mitochondrial ribosomal protein L32 (188 aa) |
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0.457 | ||||||||||
 | CHIC1 | cysteine-rich hydrophobic domain 1 (224 aa) |
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0.453 | ||||||||||
 | ENSG00000262660 | Mitochondrial dicarboxylate carrier; Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier (442 aa) |
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0.452 | ||||||||||
 | TSPAN13 | tetraspanin 13 (204 aa) |
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0.449 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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