| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNH | CDK10 | ENSP00000256897 | ENSP00000338673 | cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] | cyclin-dependent kinase 10 | 0.592 |
| CCNH | SUPT5H | ENSP00000256897 | ENSP00000404029 | cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.987 |
| CCNL1 | CDK10 | ENSP00000295926 | ENSP00000338673 | cyclin L1; Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21 | cyclin-dependent kinase 10 | 0.792 |
| CCNL1 | SUPT5H | ENSP00000295926 | ENSP00000404029 | cyclin L1; Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21 | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.580 |
| CCNL2 | CDK10 | ENSP00000383611 | ENSP00000338673 | cyclin L2 | cyclin-dependent kinase 10 | 0.785 |
| CCNL2 | SUPT5H | ENSP00000383611 | ENSP00000404029 | cyclin L2 | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.585 |
| CDK10 | CCNH | ENSP00000338673 | ENSP00000256897 | cyclin-dependent kinase 10 | cyclin H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout [...] | 0.592 |
| CDK10 | CCNL1 | ENSP00000338673 | ENSP00000295926 | cyclin-dependent kinase 10 | cyclin L1; Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21 | 0.792 |
| CDK10 | CCNL2 | ENSP00000338673 | ENSP00000383611 | cyclin-dependent kinase 10 | cyclin L2 | 0.785 |
| CDK10 | ETS2 | ENSP00000338673 | ENSP00000353344 | cyclin-dependent kinase 10 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | 0.975 |
| CDK10 | GALNS | ENSP00000338673 | ENSP00000268695 | cyclin-dependent kinase 10 | galactosamine (N-acetyl)-6-sulfate sulfatase | 0.610 |
| CDK10 | PLK5 | ENSP00000338673 | ENSP00000466248 | cyclin-dependent kinase 10 | polo-like kinase 5; Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation | 0.593 |
| CDK10 | RAF1 | ENSP00000338673 | ENSP00000251849 | cyclin-dependent kinase 10 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.596 |
| CDK10 | SUPT5H | ENSP00000338673 | ENSP00000404029 | cyclin-dependent kinase 10 | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.633 |
| CDK10 | UBC | ENSP00000338673 | ENSP00000344818 | cyclin-dependent kinase 10 | ubiquitin C | 0.778 |
| CDK10 | ZNF276 | ENSP00000338673 | ENSP00000415836 | cyclin-dependent kinase 10 | zinc finger protein 276; May be involved in transcriptional regulation | 0.764 |
| ETS2 | CDK10 | ENSP00000353344 | ENSP00000338673 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | cyclin-dependent kinase 10 | 0.975 |
| ETS2 | RAF1 | ENSP00000353344 | ENSP00000251849 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.839 |
| ETS2 | UBC | ENSP00000353344 | ENSP00000344818 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | ubiquitin C | 0.915 |
| GALNS | CDK10 | ENSP00000268695 | ENSP00000338673 | galactosamine (N-acetyl)-6-sulfate sulfatase | cyclin-dependent kinase 10 | 0.610 |
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