ASAP3 protein (Homo sapiens) - STRING network view

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ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation (903 aa)

Predicted Functional Partners:

ARF6

0.951

EZR

0.824

GRB2

0.806

RAB11A

0.676

ASAH1

0.640

RABL2B

0.633

RABL2A

0.633

RAB25

0.633

RAB11B

0.633

TXNL4B

0.608

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF6	ASAP3	ENSP00000298316	ENSP00000338769	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	0.951
ARF6	EZR	ENSP00000298316	ENSP00000338934	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis	0.705
ARF6	RAB11A	ENSP00000298316	ENSP00000261890	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...]	0.982
ARF6	RAB11B	ENSP00000298316	ENSP00000333547	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity)	0.480
ARF6	RAB25	ENSP00000298316	ENSP00000354376	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity)	0.616
ARF6	RABL2A	ENSP00000298316	ENSP00000376871	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	RAB, member of RAS oncogene family-like 2A	0.464
ARF6	RABL2B	ENSP00000298316	ENSP00000378958	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	RAB, member of RAS oncogene family-like 2B	0.464
ASAH1	ASAP3	ENSP00000371152	ENSP00000338769	N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	0.640
ASAH1	TXNL4B	ENSP00000371152	ENSP00000268483	N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	thioredoxin-like 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition	0.503
ASAP3	ARF6	ENSP00000338769	ENSP00000298316	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	0.951
ASAP3	ASAH1	ENSP00000338769	ENSP00000371152	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	N-acylsphingosine amidohydrolase (acid ceramidase) 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid	0.640
ASAP3	EZR	ENSP00000338769	ENSP00000338934	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis	0.824
ASAP3	GRB2	ENSP00000338769	ENSP00000339007	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway	0.806
ASAP3	RAB11A	ENSP00000338769	ENSP00000261890	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...]	0.676
ASAP3	RAB11B	ENSP00000338769	ENSP00000333547	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity)	0.633
ASAP3	RAB25	ENSP00000338769	ENSP00000354376	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity)	0.633
ASAP3	RABL2A	ENSP00000338769	ENSP00000376871	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	RAB, member of RAS oncogene family-like 2A	0.633
ASAP3	RABL2B	ENSP00000338769	ENSP00000378958	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	RAB, member of RAS oncogene family-like 2B	0.633
ASAP3	TXNL4B	ENSP00000338769	ENSP00000268483	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; Promotes cell proliferation	thioredoxin-like 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition	0.608
EZR	ARF6	ENSP00000338934	ENSP00000298316	ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis	ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension	0.705

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