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NRAS NRAS HRAS HRAS MRAS MRAS RAF1 RAF1 RASGRP2 RASGRP2 RAP1B RAP1B APBB1IP APBB1IP RAP1A RAP1A RRAS RRAS RAP1GAP2 RAP1GAP2 RAP1GAP RAP1GAP
"RASGRP2" - RAS guanyl releasing protein 2 (calcium and DAG-regulated) in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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RASGRP2RAS guanyl releasing protein 2 (calcium and DAG-regulated); Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway (609 aa)    
Predicted Functional Partners:
RAP1A
RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa)
        score_image score_image score_image   0.993
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image score_image score_image   0.979
RAP1B
RAP1B, member of RAS oncogene family (184 aa)
        score_image score_image score_image   0.976
RRAS
related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton (218 aa)
        score_image score_image score_image   0.976
RAP1GAP
RAP1 GTPase activating protein; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state (727 aa)
          score_image score_image   0.954
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion (666 aa)
          score_image score_image   0.951
RAP1GAP2
RAP1 GTPase activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state (730 aa)
          score_image score_image   0.942
MRAS
muscle RAS oncogene homolog; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway (208 aa)
        score_image score_image score_image   0.941
RAF1
v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] (648 aa)
          score_image score_image   0.933
HRAS
v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image score_image score_image   0.925
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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