node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM57A | GGT7 | ENSP00000312017 | ENSP00000338964 | family with sequence similarity 57, member A | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | 0.989 |
FAM57A | GSS | ENSP00000312017 | ENSP00000216951 | family with sequence similarity 57, member A | glutathione synthetase | 0.564 |
GCLC | GGT7 | ENSP00000229416 | ENSP00000338964 | glutamate-cysteine ligase, catalytic subunit | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | 0.924 |
GCLC | GPX1 | ENSP00000229416 | ENSP00000407375 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.716 |
GCLC | GPX2 | ENSP00000229416 | ENSP00000374265 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | 0.718 |
GCLC | GPX3 | ENSP00000229416 | ENSP00000373477 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | 0.549 |
GCLC | GPX4 | ENSP00000229416 | ENSP00000346103 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) | 0.533 |
GCLC | GPX6 | ENSP00000229416 | ENSP00000354581 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 6 (olfactory) | 0.422 |
GCLC | GPX7 | ENSP00000229416 | ENSP00000354677 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.488 |
GCLC | GSS | ENSP00000229416 | ENSP00000216951 | glutamate-cysteine ligase, catalytic subunit | glutathione synthetase | 0.990 |
GGT7 | FAM57A | ENSP00000338964 | ENSP00000312017 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | family with sequence similarity 57, member A | 0.989 |
GGT7 | GCLC | ENSP00000338964 | ENSP00000229416 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutamate-cysteine ligase, catalytic subunit | 0.924 |
GGT7 | GPX1 | ENSP00000338964 | ENSP00000407375 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.916 |
GGT7 | GPX2 | ENSP00000338964 | ENSP00000374265 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | 0.925 |
GGT7 | GPX3 | ENSP00000338964 | ENSP00000373477 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | 0.917 |
GGT7 | GPX4 | ENSP00000338964 | ENSP00000346103 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) | 0.919 |
GGT7 | GPX6 | ENSP00000338964 | ENSP00000354581 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 6 (olfactory) | 0.915 |
GGT7 | GPX7 | ENSP00000338964 | ENSP00000354677 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.923 |
GGT7 | GPX8 | ENSP00000338964 | ENSP00000423822 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 8 (putative) | 0.915 |
GGT7 | GSS | ENSP00000338964 | ENSP00000216951 | gamma-glutamyltransferase 7; Cleaves glutathione conjugates (By similarity) | glutathione synthetase | 0.974 |