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ULK3 ULK3 ULK2 ULK2 GABARAP GABARAP ATG13 ATG13 MAP1LC3A MAP1LC3A C12orf44 C12orf44 MAP1LC3C MAP1LC3C RB1CC1 RB1CC1 ATG5 ATG5 ULK1 ULK1 ATG16L1 ATG16L1
"C12orf44" - chromosome 12 open reading frame 44 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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Predicted Interactions
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textmining
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C12orf44chromosome 12 open reading frame 44; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation (218 aa)    
Predicted Functional Partners:
ATG13
autophagy related 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation (550 aa)
        score_image   score_image   0.998
ULK1
unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] (1050 aa)
        score_image   score_image   0.990
RB1CC1
RB1-inducible coiled-coil 1; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensib [...] (1594 aa)
        score_image   score_image   0.986
ULK2
unc-51-like kinase 2 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. [...] (1036 aa)
        score_image   score_image   0.899
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa)
      score_image score_image   score_image   0.858
ATG16L1
autophagy related 16-like 1 (S. cerevisiae) (607 aa)
        score_image   score_image   0.828
ATG5
autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) (275 aa)
        score_image   score_image   0.824
GABARAP
GABA(A) receptor-associated protein; May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity) (117 aa)
      score_image score_image   score_image   0.798
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma; Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity) (147 aa)
      score_image score_image   score_image   0.760
ULK3
unc-51-like kinase 3 (C. elegans); Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well [...] (472 aa)
        score_image   score_image   0.743
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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