| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTB | ACTG1 | ENSP00000349960 | ENSP00000331514 | actin, beta | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.943 |
| ACTB | AKT1 | ENSP00000349960 | ENSP00000270202 | actin, beta | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.755 |
| ACTB | TUBB | ENSP00000349960 | ENSP00000339001 | actin, beta | tubulin, beta class I | 0.764 |
| ACTG1 | ACTB | ENSP00000331514 | ENSP00000349960 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | actin, beta | 0.943 |
| ACTG1 | TUBB | ENSP00000331514 | ENSP00000339001 | actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | tubulin, beta class I | 0.734 |
| AKT1 | ACTB | ENSP00000270202 | ENSP00000349960 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | actin, beta | 0.755 |
| AKT1 | POTEF | ENSP00000270202 | ENSP00000350052 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | POTE ankyrin domain family, member F | 0.545 |
| AKT1 | TUBB | ENSP00000270202 | ENSP00000339001 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | tubulin, beta class I | 0.714 |
| CKAP5 | KIFC1 | ENSP00000432768 | ENSP00000393963 | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | kinesin family member C1 | 0.694 |
| CKAP5 | PCNT | ENSP00000432768 | ENSP00000352572 | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.929 |
| CKAP5 | TUBB | ENSP00000432768 | ENSP00000339001 | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | tubulin, beta class I | 0.781 |
| KIFC1 | CKAP5 | ENSP00000393963 | ENSP00000432768 | kinesin family member C1 | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | 0.694 |
| KIFC1 | TUBB | ENSP00000393963 | ENSP00000339001 | kinesin family member C1 | tubulin, beta class I | 0.704 |
| PCNT | CKAP5 | ENSP00000352572 | ENSP00000432768 | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles | 0.929 |
| PCNT | TUBB | ENSP00000352572 | ENSP00000339001 | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | tubulin, beta class I | 0.714 |
| POTEF | AKT1 | ENSP00000350052 | ENSP00000270202 | POTE ankyrin domain family, member F | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.545 |
| POTEF | TUBB | ENSP00000350052 | ENSP00000339001 | POTE ankyrin domain family, member F | tubulin, beta class I | 0.718 |
| SYT1 | TUBB | ENSP00000261205 | ENSP00000339001 | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | tubulin, beta class I | 0.761 |
| TBCA | TBCD | ENSP00000369736 | ENSP00000347719 | tubulin folding cofactor A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway | tubulin folding cofactor D | 0.992 |
| TBCA | TUBB | ENSP00000369736 | ENSP00000339001 | tubulin folding cofactor A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway | tubulin, beta class I | 0.838 |
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