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STRINGSTRING
IRS1 IRS1 CBL CBL ERBB2 ERBB2 LCP2 LCP2 SOS1 SOS1 GRB2 GRB2 EGFR EGFR GAB2 GAB2 SHC1 SHC1 FRS2 FRS2 GAB1 GAB1
"GRB2" - growth factor receptor-bound protein 2 in Homo sapiens
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protein of unknown 3D structure
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GRB2growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa)    
Predicted Functional Partners:
SOS1
son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) (1333 aa)
        score_image score_image score_image   0.999
SHC1
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
        score_image score_image score_image   0.999
EGFR
epidermal growth factor receptor (1210 aa)
        score_image score_image score_image   0.999
CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] (906 aa)
        score_image score_image score_image   0.999
GAB2
GRB2-associated binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis (676 aa)
        score_image score_image score_image   0.999
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); Involved in T-cell antigen receptor mediated signaling (533 aa)
        score_image score_image score_image   0.999
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition o [...] (1255 aa)
        score_image score_image score_image   0.999
FRS2
fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1 (508 aa)
        score_image score_image score_image   0.999
IRS1
insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) (1242 aa)
        score_image score_image score_image   0.999
GAB1
GRB2-associated binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (724 aa)
        score_image score_image score_image   0.999
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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