ESPNL protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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[Homology]

Score

ESPNL

espin-like (1005 aa)

Predicted Functional Partners:

CSTF3

0.923

RECQL

0.748

BLM

0.748

EFCAB13

0.678

EPN3

0.639

FSCN3

0.616

TTC30B

0.610

TDO2

0.591

NEURL1B

0.585

NEURL

0.585

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	ESPNL	ENSP00000347232	ENSP00000339115	Bloom syndrome, RecQ helicase-like; Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3’-5’ direction. Involved in 5’-end resection of DNA during double-strand break (DSB) repair- unwinds DNA and recruits DNA2 which mediates the cleavage of 5’-ssDNA	espin-like	0.748
CSTF3	ESPNL	ENSP00000315791	ENSP00000339115	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	espin-like	0.923
EFCAB13	EPN3	ENSP00000332111	ENSP00000268933	EF-hand calcium binding domain 13	epsin 3	0.495
EFCAB13	ESPNL	ENSP00000332111	ENSP00000339115	EF-hand calcium binding domain 13	espin-like	0.678
EPN3	EFCAB13	ENSP00000268933	ENSP00000332111	epsin 3	EF-hand calcium binding domain 13	0.495
EPN3	ESPNL	ENSP00000268933	ENSP00000339115	epsin 3	espin-like	0.639
EPN3	NEURL	ENSP00000268933	ENSP00000358795	epsin 3	neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity)	0.631
EPN3	NEURL1B	ENSP00000268933	ENSP00000358815	epsin 3	neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands	0.679
ESPNL	BLM	ENSP00000339115	ENSP00000347232	espin-like	Bloom syndrome, RecQ helicase-like; Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3’-5’ direction. Involved in 5’-end resection of DNA during double-strand break (DSB) repair- unwinds DNA and recruits DNA2 which mediates the cleavage of 5’-ssDNA	0.748
ESPNL	CSTF3	ENSP00000339115	ENSP00000315791	espin-like	cleavage stimulation factor, 3’ pre-RNA, subunit 3, 77kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs	0.923
ESPNL	EFCAB13	ENSP00000339115	ENSP00000332111	espin-like	EF-hand calcium binding domain 13	0.678
ESPNL	EPN3	ENSP00000339115	ENSP00000268933	espin-like	epsin 3	0.639
ESPNL	FSCN3	ENSP00000339115	ENSP00000265825	espin-like	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity)	0.616
ESPNL	NEURL	ENSP00000339115	ENSP00000358795	espin-like	neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity)	0.585
ESPNL	NEURL1B	ENSP00000339115	ENSP00000358815	espin-like	neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands	0.585
ESPNL	RECQL	ENSP00000339115	ENSP00000395449	espin-like	RecQ protein-like (DNA helicase Q1-like); DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3’-5’ direction	0.748
ESPNL	TDO2	ENSP00000339115	ENSP00000444788	espin-like	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.591
ESPNL	TTC30B	ENSP00000339115	ENSP00000386181	espin-like	tetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.610
FSCN3	ESPNL	ENSP00000265825	ENSP00000339115	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity)	espin-like	0.616
FSCN3	TDO2	ENSP00000265825	ENSP00000444788	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity)	tryptophan 2,3-dioxygenase; Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)	0.485

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