RRP1B protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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[Homology]

Score

RRP1B

ribosomal RNA processing 1 homolog B (S. cerevisiae) (758 aa)

Predicted Functional Partners:

NOP2

0.985

BRIX1

0.977

WDR12

0.976

DDX27

0.970

CEBPZ

0.967

NOC2L

0.963

BOP1

0.963

RPF2

0.963

NIP7

0.962

ENSG00000204775

0.962

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	BRIX1	ENSP00000304151	ENSP00000338862	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	0.989
BOP1	CEBPZ	ENSP00000304151	ENSP00000234170	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	CCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter	0.950
BOP1	DDX27	ENSP00000304151	ENSP00000360828	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	0.983
BOP1	NIP7	ENSP00000304151	ENSP00000254940	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.972
BOP1	NOC2L	ENSP00000304151	ENSP00000317992	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter	0.984
BOP1	NOP2	ENSP00000304151	ENSP00000382392	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.996
BOP1	RPF2	ENSP00000304151	ENSP00000402338	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	ribosome production factor 2 homolog (S. cerevisiae)	0.989
BOP1	RRP1B	ENSP00000304151	ENSP00000339145	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	ribosomal RNA processing 1 homolog B (S. cerevisiae)	0.963
BOP1	WDR12	ENSP00000304151	ENSP00000261015	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.999
BRIX1	BOP1	ENSP00000338862	ENSP00000304151	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.989
BRIX1	CEBPZ	ENSP00000338862	ENSP00000234170	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	CCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter	0.988
BRIX1	DDX27	ENSP00000338862	ENSP00000360828	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	0.988
BRIX1	ENSG00000204775	ENSP00000338862	ENSP00000366629	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	KM-PA-2 protein; Uncharacterized protein	0.989
BRIX1	NIP7	ENSP00000338862	ENSP00000254940	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.998
BRIX1	NOC2L	ENSP00000338862	ENSP00000317992	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter	0.993
BRIX1	NOP2	ENSP00000338862	ENSP00000382392	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase	0.994
BRIX1	RPF2	ENSP00000338862	ENSP00000402338	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ribosome production factor 2 homolog (S. cerevisiae)	0.998
BRIX1	RRP1B	ENSP00000338862	ENSP00000339145	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	ribosomal RNA processing 1 homolog B (S. cerevisiae)	0.977
BRIX1	WDR12	ENSP00000338862	ENSP00000261015	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit	WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.998
CEBPZ	BOP1	ENSP00000234170	ENSP00000304151	CCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.950

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