| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIDA | FAM118A | ENSP00000339161 | ENSP00000216214 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | family with sequence similarity 118, member A | 0.601 |
| AIDA | GSK3B | ENSP00000339161 | ENSP00000324806 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | 0.499 |
| AIDA | LOH12CR1 | ENSP00000339161 | ENSP00000321546 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | loss of heterozygosity, 12, chromosomal region 1 | 0.474 |
| AIDA | LSM14B | ENSP00000339161 | ENSP00000279068 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) | 0.412 |
| AIDA | NIPAL1 | ENSP00000339161 | ENSP00000295461 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | 0.405 |
| AIDA | NLRP9 | ENSP00000339161 | ENSP00000331857 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | NLR family, pyrin domain containing 9; Involved in inflammation (Potential) | 0.416 |
| FAM118A | AIDA | ENSP00000216214 | ENSP00000339161 | family with sequence similarity 118, member A | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.601 |
| GSK3B | AIDA | ENSP00000324806 | ENSP00000339161 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.499 |
| LOH12CR1 | AIDA | ENSP00000321546 | ENSP00000339161 | loss of heterozygosity, 12, chromosomal region 1 | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.474 |
| LOH12CR1 | LSM14B | ENSP00000321546 | ENSP00000279068 | loss of heterozygosity, 12, chromosomal region 1 | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) | 0.407 |
| LSM14B | AIDA | ENSP00000279068 | ENSP00000339161 | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.412 |
| LSM14B | LOH12CR1 | ENSP00000279068 | ENSP00000321546 | LSM14B, SCD6 homolog B (S. cerevisiae); May play a role in control of mRNA translation (By similarity) | loss of heterozygosity, 12, chromosomal region 1 | 0.407 |
| NIPAL1 | AIDA | ENSP00000295461 | ENSP00000339161 | NIPA-like domain containing 1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.405 |
| NLRP9 | AIDA | ENSP00000331857 | ENSP00000339161 | NLR family, pyrin domain containing 9; Involved in inflammation (Potential) | axin interactor, dorsalization associated; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity) | 0.416 |
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