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PHLPP1 PHLPP1 PHLPP2 PHLPP2 PPM1L PPM1L LRGUK LRGUK PPTC7 PPTC7 HSPA8 HSPA8 PP2D1 PP2D1 TSSK4 TSSK4 CREB1 CREB1 TBC1D21 TBC1D21 TSKS TSKS
"TSSK4" - testis-specific serine kinase 4 in Homo sapiens
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Predicted Interactions
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TSSK4testis-specific serine kinase 4; May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling (338 aa)    
Predicted Functional Partners:
CREB1
cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (341 aa)
        score_image   score_image   0.959
TBC1D21
TBC1 domain family, member 21; May act as a GTPase-activating protein for Rab family protein(s) (336 aa)
        score_image   score_image   0.827
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] (1323 aa)
score_image       score_image   score_image   0.788
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] (1717 aa)
score_image       score_image   score_image   0.788
TSKS
testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development (592 aa)
            score_image   0.725
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
        score_image   score_image   0.714
LRGUK
leucine-rich repeats and guanylate kinase domain containing (825 aa)
score_image       score_image   score_image   0.688
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae) (304 aa)
score_image     score_image score_image   score_image   0.661
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 (360 aa)
score_image       score_image   score_image   0.659
PP2D1
protein phosphatase 2C-like domain containing 1 (630 aa)
score_image       score_image   score_image   0.659
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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