SLC6A13 protein (Homo sapiens) - STRING network view

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SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (602 aa)

Predicted Functional Partners:

GABRD

0.765

GABRA5

0.753

GGT1

0.750

GGT2

0.749

GAD1

0.576

SLC1A3

0.570

SLC1A2

0.566

SLC7A3

0.561

GATS

0.540

PRDM10

0.539

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GABRA5	GABRD	ENSP00000335592	ENSP00000367848	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.597
GABRA5	SLC6A13	ENSP00000335592	ENSP00000339260	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.753
GABRD	GABRA5	ENSP00000367848	ENSP00000335592	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.597
GABRD	GAD1	ENSP00000367848	ENSP00000350928	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.539
GABRD	SLC6A13	ENSP00000367848	ENSP00000339260	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.765
GAD1	GABRD	ENSP00000350928	ENSP00000367848	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.539
GAD1	GGT1	ENSP00000350928	ENSP00000248923	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.917
GAD1	SLC1A2	ENSP00000350928	ENSP00000278379	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 1 (glial high affinity glutamate transporter), member 2; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	0.464
GAD1	SLC1A3	ENSP00000350928	ENSP00000265113	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 1 (glial high affinity glutamate transporter), member 3; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium	0.472
GAD1	SLC6A13	ENSP00000350928	ENSP00000339260	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.576
GATS	SLC6A13	ENSP00000389760	ENSP00000339260	Putative protein GATS	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.540
GGT1	GAD1	ENSP00000248923	ENSP00000350928	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.917
GGT1	PRDM10	ENSP00000248923	ENSP00000351686	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	PR domain containing 10	0.851
GGT1	SLC6A13	ENSP00000248923	ENSP00000339260	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.750
GGT1	SLC7A3	ENSP00000248923	ENSP00000298085	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner	0.739
GGT2	PRDM10	ENSP00000385721	ENSP00000351686	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	PR domain containing 10	0.850
GGT2	SLC6A13	ENSP00000385721	ENSP00000339260	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	solute carrier family 6 (neurotransmitter transporter, GABA), member 13; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport	0.749
GGT2	SLC7A3	ENSP00000385721	ENSP00000298085	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner	0.738
PRDM10	GGT1	ENSP00000351686	ENSP00000248923	PR domain containing 10	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.851
PRDM10	GGT2	ENSP00000351686	ENSP00000385721	PR domain containing 10	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	0.850

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