node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD6 | ZNF70 | ENSP00000323280 | ENSP00000339314 | CD6 molecule; Involved in cell adhesion. Binds to CD166 | zinc finger protein 70; May be involved in transcriptional regulation | 0.502 |
FBXL19 | ZNF69 | ENSP00000369666 | ENSP00000345333 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 69; May be involved in transcriptional regulation | 0.501 |
FBXL19 | ZNF70 | ENSP00000369666 | ENSP00000339314 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 70; May be involved in transcriptional regulation | 0.501 |
FEN1 | ZNF70 | ENSP00000305480 | ENSP00000339314 | flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] | zinc finger protein 70; May be involved in transcriptional regulation | 0.498 |
KDM2A | ZNF69 | ENSP00000432786 | ENSP00000345333 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 69; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF70 | ENSP00000432786 | ENSP00000339314 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 70; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF69 | ENSP00000366271 | ENSP00000345333 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 69; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF70 | ENSP00000366271 | ENSP00000339314 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 70; May be involved in transcriptional regulation | 0.501 |
PTPN23 | ZNF69 | ENSP00000265562 | ENSP00000345333 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 69; May be involved in transcriptional regulation | 0.476 |
PTPN23 | ZNF70 | ENSP00000265562 | ENSP00000339314 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 70; May be involved in transcriptional regulation | 0.476 |
RNF126 | ZNF70 | ENSP00000292363 | ENSP00000339314 | ring finger protein 126 | zinc finger protein 70; May be involved in transcriptional regulation | 0.472 |
SRP9 | ZNF70 | ENSP00000305230 | ENSP00000339314 | signal recognition particle 9kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding | zinc finger protein 70; May be involved in transcriptional regulation | 0.611 |
XRN1 | ZNF69 | ENSP00000264951 | ENSP00000345333 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 69; May be involved in transcriptional regulation | 0.543 |
XRN1 | ZNF70 | ENSP00000264951 | ENSP00000339314 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 70; May be involved in transcriptional regulation | 0.543 |
ZNF69 | FBXL19 | ENSP00000345333 | ENSP00000369666 | zinc finger protein 69; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF69 | KDM2A | ENSP00000345333 | ENSP00000432786 | zinc finger protein 69; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF69 | KDM2B | ENSP00000345333 | ENSP00000366271 | zinc finger protein 69; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF69 | PTPN23 | ENSP00000345333 | ENSP00000265562 | zinc finger protein 69; May be involved in transcriptional regulation | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |
ZNF69 | XRN1 | ENSP00000345333 | ENSP00000264951 | zinc finger protein 69; May be involved in transcriptional regulation | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.543 |
ZNF69 | ZNF70 | ENSP00000345333 | ENSP00000339314 | zinc finger protein 69; May be involved in transcriptional regulation | zinc finger protein 70; May be involved in transcriptional regulation | 0.886 |