NPY5R protein (Homo sapiens) - STRING network view

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NPY5R

neuropeptide Y receptor Y5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (445 aa)

Predicted Functional Partners:

NPY

0.980

PYY

0.968

PPY

0.930

POMC

0.925

GAL

0.925

GRM8

0.922

NPY1R

0.921

NPBWR2

0.921

NPY2R

0.921

GRM3

0.916

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAL	GRM3	ENSP00000265643	ENSP00000355316	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	0.906
GAL	GRM8	ENSP00000265643	ENSP00000344173	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	glutamate receptor, metabotropic 8	0.904
GAL	NPBWR2	ENSP00000265643	ENSP00000358783	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptides B/W receptor 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals	0.914
GAL	NPY	ENSP00000265643	ENSP00000242152	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.990
GAL	NPY1R	ENSP00000265643	ENSP00000354652	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid	0.992
GAL	NPY2R	ENSP00000265643	ENSP00000332591	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid	0.918
GAL	NPY5R	ENSP00000265643	ENSP00000339377	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	neuropeptide Y receptor Y5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders	0.925
GAL	POMC	ENSP00000265643	ENSP00000264708	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.971
GAL	PPY	ENSP00000265643	ENSP00000225992	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	0.960
GAL	PYY	ENSP00000265643	ENSP00000353198	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility	0.943
GRM3	GAL	ENSP00000355316	ENSP00000265643	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion	0.906
GRM3	GRM8	ENSP00000355316	ENSP00000344173	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	glutamate receptor, metabotropic 8	0.905
GRM3	NPBWR2	ENSP00000355316	ENSP00000358783	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	neuropeptides B/W receptor 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals	0.902
GRM3	NPY	ENSP00000355316	ENSP00000242152	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.922
GRM3	NPY1R	ENSP00000355316	ENSP00000354652	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid	0.912
GRM3	NPY2R	ENSP00000355316	ENSP00000332591	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid	0.917
GRM3	NPY5R	ENSP00000355316	ENSP00000339377	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	neuropeptide Y receptor Y5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders	0.916
GRM3	POMC	ENSP00000355316	ENSP00000264708	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.910
GRM3	PPY	ENSP00000355316	ENSP00000225992	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	0.900
GRM3	PYY	ENSP00000355316	ENSP00000353198	glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility	0.900

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