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STRINGSTRING
TRIM31 TRIM31 HOXA1 HOXA1 GSDMA GSDMA DFNA5 DFNA5 CHCHD6 CHCHD6 TECTA TECTA SLC6A8 SLC6A8 TP53 TP53 UBC UBC ZFAND5 ZFAND5 PDXP PDXP
"DFNA5" - deafness, autosomal dominant 5 in Homo sapiens
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protein of unknown 3D structure
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DFNA5deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (496 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.853
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
            score_image   0.847
GSDMA
gasdermin A; Induces apoptosis (445 aa)
            score_image   0.817
HOXA1
homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (335 aa)
            score_image   0.745
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption (235 aa)
            score_image   0.591
TECTA
tectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (2155 aa)
            score_image   0.538
TRIM31
tripartite motif containing 31 (425 aa)
            score_image   0.478
ZFAND5
zinc finger, AN1-type domain 5; Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a pote [...] (213 aa)
            score_image   0.463
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Required for the uptake of creatine in muscles and brain (635 aa)
            score_image   0.447
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] (296 aa)
            score_image   0.431
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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