node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD6 | DFNA5 | ENSP00000290913 | ENSP00000339587 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.591 |
CHCHD6 | UBC | ENSP00000290913 | ENSP00000344818 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | ubiquitin C | 0.495 |
DFNA5 | CHCHD6 | ENSP00000339587 | ENSP00000290913 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | coiled-coil-helix-coiled-coil-helix domain containing 6; Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption | 0.591 |
DFNA5 | GSDMA | ENSP00000339587 | ENSP00000301659 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | gasdermin A; Induces apoptosis | 0.817 |
DFNA5 | HOXA1 | ENSP00000339587 | ENSP00000343246 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments | 0.745 |
DFNA5 | PDXP | ENSP00000339587 | ENSP00000215904 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | 0.431 |
DFNA5 | SLC6A8 | ENSP00000339587 | ENSP00000253122 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Required for the uptake of creatine in muscles and brain | 0.447 |
DFNA5 | TECTA | ENSP00000339587 | ENSP00000264037 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | tectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.538 |
DFNA5 | TP53 | ENSP00000339587 | ENSP00000269305 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.847 |
DFNA5 | TRIM31 | ENSP00000339587 | ENSP00000365924 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | tripartite motif containing 31 | 0.478 |
DFNA5 | UBC | ENSP00000339587 | ENSP00000344818 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | ubiquitin C | 0.853 |
DFNA5 | ZFAND5 | ENSP00000339587 | ENSP00000237937 | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | zinc finger, AN1-type domain 5; Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a pote [...] | 0.463 |
GSDMA | DFNA5 | ENSP00000301659 | ENSP00000339587 | gasdermin A; Induces apoptosis | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.817 |
HOXA1 | DFNA5 | ENSP00000343246 | ENSP00000339587 | homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.745 |
PDXP | DFNA5 | ENSP00000215904 | ENSP00000339587 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.431 |
PDXP | UBC | ENSP00000215904 | ENSP00000344818 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | ubiquitin C | 0.453 |
SLC6A8 | DFNA5 | ENSP00000253122 | ENSP00000339587 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Required for the uptake of creatine in muscles and brain | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.447 |
SLC6A8 | ZFAND5 | ENSP00000253122 | ENSP00000237937 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8; Required for the uptake of creatine in muscles and brain | zinc finger, AN1-type domain 5; Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a pote [...] | 0.412 |
TECTA | DFNA5 | ENSP00000264037 | ENSP00000339587 | tectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.538 |
TP53 | DFNA5 | ENSP00000269305 | ENSP00000339587 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | deafness, autosomal dominant 5; Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.847 |