POFUT2 protein (Homo sapiens) - STRING network view

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POFUT2

protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...] (429 aa)

Predicted Functional Partners:

B3GALTL

0.973

POFUT1

0.969

THBS1

0.966

ADAMTSL1

0.948

CFP

0.935

ADAMTSL4

0.910

ADAMTS5

0.910

ADAMTS7

0.900

PADI2

0.811

ADARB1

0.801

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS5	ADAMTS7	ENSP00000284987	ENSP00000373472	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	0.916
ADAMTS5	ADAMTSL1	ENSP00000284987	ENSP00000369921	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	ADAMTS-like 1	0.912
ADAMTS5	ADAMTSL4	ENSP00000284987	ENSP00000271643	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis	0.906
ADAMTS5	B3GALTL	ENSP00000284987	ENSP00000343002	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	beta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan	0.900
ADAMTS5	CFP	ENSP00000284987	ENSP00000247153	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.906
ADAMTS5	POFUT2	ENSP00000284987	ENSP00000339613	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	0.910
ADAMTS5	THBS1	ENSP00000284987	ENSP00000260356	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties	0.915
ADAMTS7	ADAMTS5	ENSP00000373472	ENSP00000284987	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	0.916
ADAMTS7	ADAMTSL1	ENSP00000373472	ENSP00000369921	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	ADAMTS-like 1	0.913
ADAMTS7	ADAMTSL4	ENSP00000373472	ENSP00000271643	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis	0.904
ADAMTS7	B3GALTL	ENSP00000373472	ENSP00000343002	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	beta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan	0.900
ADAMTS7	CFP	ENSP00000373472	ENSP00000247153	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.900
ADAMTS7	POFUT2	ENSP00000373472	ENSP00000339613	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	0.900
ADAMTS7	THBS1	ENSP00000373472	ENSP00000260356	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties	0.916
ADAMTSL1	ADAMTS5	ENSP00000369921	ENSP00000284987	ADAMTS-like 1	ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period	0.912
ADAMTSL1	ADAMTS7	ENSP00000369921	ENSP00000373472	ADAMTS-like 1	ADAM metallopeptidase with thrombospondin type 1 motif, 7; Metalloprotease that may play a role in the degradation of COMP	0.913
ADAMTSL1	ADAMTSL4	ENSP00000369921	ENSP00000271643	ADAMTS-like 1	ADAMTS-like 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis	0.921
ADAMTSL1	B3GALTL	ENSP00000369921	ENSP00000343002	ADAMTS-like 1	beta 1,3-galactosyltransferase-like; O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan	0.929
ADAMTSL1	CFP	ENSP00000369921	ENSP00000247153	ADAMTS-like 1	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.924
ADAMTSL1	POFUT2	ENSP00000369921	ENSP00000339613	ADAMTS-like 1	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	0.948

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