node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HRAS | KRAS | ENSP00000309845 | ENSP00000256078 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | NRAS | ENSP00000309845 | ENSP00000358548 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | RASSF4 | ENSP00000309845 | ENSP00000339692 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.818 |
KRAS | HRAS | ENSP00000256078 | ENSP00000309845 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | NRAS | ENSP00000256078 | ENSP00000358548 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | RASSF4 | ENSP00000256078 | ENSP00000339692 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.815 |
MST1 | RASSF4 | ENSP00000414287 | ENSP00000339692 | macrophage stimulating 1 (hepatocyte growth factor-like) | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.999 |
MST1 | SAV1 | ENSP00000414287 | ENSP00000324729 | macrophage stimulating 1 (hepatocyte growth factor-like) | salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] | 0.999 |
MST1 | STK3 | ENSP00000414287 | ENSP00000390500 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.986 |
MST1 | STK4 | ENSP00000414287 | ENSP00000361892 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
MST4 | RASSF4 | ENSP00000377867 | ENSP00000339692 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.655 |
MST4 | SAV1 | ENSP00000377867 | ENSP00000324729 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | salvador homolog 1 (Drosophila); Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the n [...] | 0.494 |
MST4 | STK24 | ENSP00000377867 | ENSP00000365730 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] | 0.999 |
NRAS | HRAS | ENSP00000358548 | ENSP00000309845 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | KRAS | ENSP00000358548 | ENSP00000256078 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | RASSF4 | ENSP00000358548 | ENSP00000339692 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.810 |
PAWR | RASSF4 | ENSP00000328088 | ENSP00000339692 | PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by [...] | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | 0.812 |
RASSF4 | HRAS | ENSP00000339692 | ENSP00000309845 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.818 |
RASSF4 | KRAS | ENSP00000339692 | ENSP00000256078 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.815 |
RASSF4 | MST1 | ENSP00000339692 | ENSP00000414287 | Ras association (RalGDS/AF-6) domain family member 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest | macrophage stimulating 1 (hepatocyte growth factor-like) | 0.999 |