node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSJ | IDS | ENSP00000320219 | ENSP00000339801 | arylsulfatase family, member J | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | 0.523 |
ARSJ | SUMF1 | ENSP00000320219 | ENSP00000272902 | arylsulfatase family, member J | sulfatase modifying factor 1 | 0.959 |
ARSJ | SUMF2 | ENSP00000320219 | ENSP00000341938 | arylsulfatase family, member J | sulfatase modifying factor 2 | 0.952 |
GNS | IDS | ENSP00000258145 | ENSP00000339801 | glucosamine (N-acetyl)-6-sulfatase | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | 0.465 |
GNS | SUMF1 | ENSP00000258145 | ENSP00000272902 | glucosamine (N-acetyl)-6-sulfatase | sulfatase modifying factor 1 | 0.679 |
GNS | SUMF2 | ENSP00000258145 | ENSP00000341938 | glucosamine (N-acetyl)-6-sulfatase | sulfatase modifying factor 2 | 0.532 |
IDS | ARSJ | ENSP00000339801 | ENSP00000320219 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | arylsulfatase family, member J | 0.523 |
IDS | GNS | ENSP00000339801 | ENSP00000258145 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | glucosamine (N-acetyl)-6-sulfatase | 0.465 |
IDS | SET | ENSP00000339801 | ENSP00000361777 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | SET nuclear oncogene; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibilit [...] | 0.417 |
IDS | SUMF1 | ENSP00000339801 | ENSP00000272902 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | sulfatase modifying factor 1 | 0.536 |
IDS | SUMF2 | ENSP00000339801 | ENSP00000341938 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | sulfatase modifying factor 2 | 0.468 |
SET | IDS | ENSP00000361777 | ENSP00000339801 | SET nuclear oncogene; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibilit [...] | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | 0.417 |
SUMF1 | ARSJ | ENSP00000272902 | ENSP00000320219 | sulfatase modifying factor 1 | arylsulfatase family, member J | 0.959 |
SUMF1 | GNS | ENSP00000272902 | ENSP00000258145 | sulfatase modifying factor 1 | glucosamine (N-acetyl)-6-sulfatase | 0.679 |
SUMF1 | IDS | ENSP00000272902 | ENSP00000339801 | sulfatase modifying factor 1 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | 0.536 |
SUMF1 | SUMF2 | ENSP00000272902 | ENSP00000341938 | sulfatase modifying factor 1 | sulfatase modifying factor 2 | 0.927 |
SUMF2 | ARSJ | ENSP00000341938 | ENSP00000320219 | sulfatase modifying factor 2 | arylsulfatase family, member J | 0.952 |
SUMF2 | GNS | ENSP00000341938 | ENSP00000258145 | sulfatase modifying factor 2 | glucosamine (N-acetyl)-6-sulfatase | 0.532 |
SUMF2 | IDS | ENSP00000341938 | ENSP00000339801 | sulfatase modifying factor 2 | iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate | 0.468 |
SUMF2 | SUMF1 | ENSP00000341938 | ENSP00000272902 | sulfatase modifying factor 2 | sulfatase modifying factor 1 | 0.927 |