TSPAN18 protein (Homo sapiens) - STRING network view

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TSPAN18

tetraspanin 18 (248 aa)

Predicted Functional Partners:

TSPAN15

0.702

TSPAN13

0.639

TSPAN31

0.614

DYSF

0.560

FER1L6

0.560

MYOF

0.560

OTOF

0.560

SIPA1

0.542

NME3

0.539

PGBD1

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DYSF	TSPAN18	ENSP00000386881	ENSP00000339820	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	tetraspanin 18	0.560
FER1L6	TSPAN18	ENSP00000381982	ENSP00000339820	fer-1-like 6 (C. elegans)	tetraspanin 18	0.560
MYOF	TSPAN18	ENSP00000352208	ENSP00000339820	myoferlin	tetraspanin 18	0.560
NME3	SIPA1	ENSP00000219302	ENSP00000377771	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	signal-induced proliferation-associated 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state	0.606
NME3	TSPAN18	ENSP00000219302	ENSP00000339820	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	tetraspanin 18	0.539
OTOF	TSPAN18	ENSP00000272371	ENSP00000339820	otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity)	tetraspanin 18	0.560
PGBD1	TSPAN18	ENSP00000259883	ENSP00000339820	piggyBac transposable element derived 1	tetraspanin 18	0.529
SIPA1	NME3	ENSP00000377771	ENSP00000219302	signal-induced proliferation-associated 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	0.606
SIPA1	TSPAN18	ENSP00000377771	ENSP00000339820	signal-induced proliferation-associated 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state	tetraspanin 18	0.542
TSPAN13	TSPAN15	ENSP00000262067	ENSP00000362387	tetraspanin 13	tetraspanin 15	0.686
TSPAN13	TSPAN18	ENSP00000262067	ENSP00000339820	tetraspanin 13	tetraspanin 18	0.639
TSPAN15	TSPAN13	ENSP00000362387	ENSP00000262067	tetraspanin 15	tetraspanin 13	0.686
TSPAN15	TSPAN18	ENSP00000362387	ENSP00000339820	tetraspanin 15	tetraspanin 18	0.702
TSPAN15	TSPAN31	ENSP00000362387	ENSP00000257910	tetraspanin 15	tetraspanin 31	0.582
TSPAN18	DYSF	ENSP00000339820	ENSP00000386881	tetraspanin 18	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.560
TSPAN18	FER1L6	ENSP00000339820	ENSP00000381982	tetraspanin 18	fer-1-like 6 (C. elegans)	0.560
TSPAN18	MYOF	ENSP00000339820	ENSP00000352208	tetraspanin 18	myoferlin	0.560
TSPAN18	NME3	ENSP00000339820	ENSP00000219302	tetraspanin 18	NME/NM23 nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis	0.539
TSPAN18	OTOF	ENSP00000339820	ENSP00000272371	tetraspanin 18	otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity)	0.560
TSPAN18	PGBD1	ENSP00000339820	ENSP00000259883	tetraspanin 18	piggyBac transposable element derived 1	0.529

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