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STRINGSTRING
C19orf47 C19orf47 SAMD4B SAMD4B LRFN1 LRFN1 TTC9B TTC9B KDM2A KDM2A ZNF546 ZNF546 LRRC66 LRRC66 TAF1L TAF1L ZFAND4 ZFAND4 ECD ECD XRN1 XRN1
"ZNF546" - zinc finger protein 546 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ZNF546zinc finger protein 546; May be involved in transcriptional regulation (836 aa)    
Predicted Functional Partners:
C19orf47
chromosome 19 open reading frame 47 (422 aa)
            score_image   0.722
TTC9B
tetratricopeptide repeat domain 9B (239 aa)
            score_image   0.722
LRRC66
leucine rich repeat containing 66 (880 aa)
        score_image   score_image   0.673
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced (1826 aa)
        score_image   score_image   0.633
ZFAND4
zinc finger, AN1-type domain 4 (727 aa)
        score_image   score_image   0.625
ECD
ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes (677 aa)
            score_image   0.577
XRN1
5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) (1706 aa)
      score_image score_image   score_image   0.543
SAMD4B
sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (694 aa)
            score_image   0.539
LRFN1
leucine rich repeat and fibronectin type III domain containing 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity) (771 aa)
        score_image   score_image   0.526
KDM2A
lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] (1162 aa)
        score_image   score_image   0.501
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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