node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FGFR1 | FLRT3 | ENSP00000393312 | ENSP00000339912 | fibroblast growth factor receptor 1 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.644 |
FLRT3 | FGFR1 | ENSP00000339912 | ENSP00000393312 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | fibroblast growth factor receptor 1 | 0.644 |
FLRT3 | MACROD2 | ENSP00000339912 | ENSP00000217246 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.888 |
FLRT3 | MLL2 | ENSP00000339912 | ENSP00000301067 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | 0.692 |
FLRT3 | NID1 | ENSP00000339912 | ENSP00000264187 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | 0.564 |
FLRT3 | POTEE | ENSP00000339912 | ENSP00000439189 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | POTE ankyrin domain family member E | 0.526 |
FLRT3 | POTEI | ENSP00000339912 | ENSP00000392718 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | POTE ankyrin domain family, member I | 0.526 |
FLRT3 | RND1 | ENSP00000339912 | ENSP00000308461 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments | 0.798 |
FLRT3 | UNC5B | ENSP00000339912 | ENSP00000334329 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.759 |
FLRT3 | UNC5C | ENSP00000339912 | ENSP00000406022 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.759 |
FLRT3 | UNC5D | ENSP00000339912 | ENSP00000385143 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.659 |
MACROD2 | FLRT3 | ENSP00000217246 | ENSP00000339912 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.888 |
MACROD2 | MLL2 | ENSP00000217246 | ENSP00000301067 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | 0.748 |
MLL2 | FLRT3 | ENSP00000301067 | ENSP00000339912 | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.692 |
MLL2 | MACROD2 | ENSP00000301067 | ENSP00000217246 | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.748 |
NID1 | FLRT3 | ENSP00000264187 | ENSP00000339912 | nidogen 1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.564 |
POTEE | FLRT3 | ENSP00000439189 | ENSP00000339912 | POTE ankyrin domain family member E | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.526 |
POTEE | RND1 | ENSP00000439189 | ENSP00000308461 | POTE ankyrin domain family member E | Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments | 0.608 |
POTEI | FLRT3 | ENSP00000392718 | ENSP00000339912 | POTE ankyrin domain family, member I | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.526 |
POTEI | RND1 | ENSP00000392718 | ENSP00000308461 | POTE ankyrin domain family, member I | Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments | 0.608 |