| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANXA1 | APP | ENSP00000257497 | ENSP00000284981 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | amyloid beta (A4) precursor protein | 0.925 |
| ANXA1 | CXCL12 | ENSP00000257497 | ENSP00000379140 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | chemokine (C-X-C motif) ligand 12 | 0.910 |
| ANXA1 | CXCL6 | ENSP00000257497 | ENSP00000226317 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | chemokine (C-X-C motif) ligand 6; Chemotactic for neutrophil granulocytes | 0.902 |
| ANXA1 | FPR2 | ENSP00000257497 | ENSP00000340191 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) | 0.973 |
| ANXA1 | HEBP1 | ENSP00000257497 | ENSP00000014930 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | heme binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities | 0.900 |
| ANXA1 | IL8 | ENSP00000257497 | ENSP00000306512 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | interleukin 8 | 0.916 |
| ANXA1 | MTRNR2L2 | ENSP00000257497 | ENSP00000468991 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | MT-RNR2-like 2; Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP | 0.900 |
| ANXA1 | SAA1 | ENSP00000257497 | ENSP00000348918 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.905 |
| APP | ANXA1 | ENSP00000284981 | ENSP00000257497 | amyloid beta (A4) precursor protein | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | 0.925 |
| APP | CXCL12 | ENSP00000284981 | ENSP00000379140 | amyloid beta (A4) precursor protein | chemokine (C-X-C motif) ligand 12 | 0.912 |
| APP | CXCL6 | ENSP00000284981 | ENSP00000226317 | amyloid beta (A4) precursor protein | chemokine (C-X-C motif) ligand 6; Chemotactic for neutrophil granulocytes | 0.900 |
| APP | FPR2 | ENSP00000284981 | ENSP00000340191 | amyloid beta (A4) precursor protein | formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) | 0.928 |
| APP | HEBP1 | ENSP00000284981 | ENSP00000014930 | amyloid beta (A4) precursor protein | heme binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities | 0.900 |
| APP | IL8 | ENSP00000284981 | ENSP00000306512 | amyloid beta (A4) precursor protein | interleukin 8 | 0.916 |
| APP | MTRNR2L2 | ENSP00000284981 | ENSP00000468991 | amyloid beta (A4) precursor protein | MT-RNR2-like 2; Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP | 0.917 |
| APP | SAA1 | ENSP00000284981 | ENSP00000348918 | amyloid beta (A4) precursor protein | serum amyloid A1; Major acute phase reactant. Apolipoprotein of the HDL complex (By similarity) | 0.921 |
| CAMP | FPR2 | ENSP00000458149 | ENSP00000340191 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) | 0.983 |
| CAMP | IL8 | ENSP00000458149 | ENSP00000306512 | cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity | interleukin 8 | 0.908 |
| CXCL12 | ANXA1 | ENSP00000379140 | ENSP00000257497 | chemokine (C-X-C motif) ligand 12 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | 0.910 |
| CXCL12 | APP | ENSP00000379140 | ENSP00000284981 | chemokine (C-X-C motif) ligand 12 | amyloid beta (A4) precursor protein | 0.912 |
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