| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSM1 | GLYAT | ENSP00000301956 | ENSP00000340200 | acyl-CoA synthetase medium-chain family member 1; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity) | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.916 |
| ACSM2B | GLYAT | ENSP00000327453 | ENSP00000340200 | acyl-CoA synthetase medium-chain family member 2B; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.900 |
| AGA | FLVCR2 | ENSP00000264595 | ENSP00000238667 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | 0.720 |
| AGA | GAA | ENSP00000264595 | ENSP00000305692 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | 0.943 |
| AGA | GGCT | ENSP00000264595 | ENSP00000275428 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.883 |
| AGA | GLYAT | ENSP00000264595 | ENSP00000340200 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.720 |
| AGA | MPG | ENSP00000264595 | ENSP00000219431 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | N-methylpurine-DNA glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions | 0.757 |
| AGA | QPCT | ENSP00000264595 | ENSP00000344829 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.892 |
| BAAT | GLYAT | ENSP00000259407 | ENSP00000340200 | bile acid CoA- amino acid N-acyltransferase (glycine N-choloyltransferase); Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation [...] | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.763 |
| FLVCR2 | AGA | ENSP00000238667 | ENSP00000264595 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | 0.720 |
| FLVCR2 | GAA | ENSP00000238667 | ENSP00000305692 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | 0.723 |
| FLVCR2 | GGCT | ENSP00000238667 | ENSP00000275428 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.725 |
| FLVCR2 | GLYAT | ENSP00000238667 | ENSP00000340200 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.755 |
| FLVCR2 | MPG | ENSP00000238667 | ENSP00000219431 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | N-methylpurine-DNA glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions | 0.728 |
| FLVCR2 | QPCT | ENSP00000238667 | ENSP00000344829 | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.724 |
| GAA | AGA | ENSP00000305692 | ENSP00000264595 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | 0.943 |
| GAA | FLVCR2 | ENSP00000305692 | ENSP00000238667 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | feline leukemia virus subgroup C cellular receptor family, member 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism | 0.723 |
| GAA | GGCT | ENSP00000305692 | ENSP00000275428 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.887 |
| GAA | GLYAT | ENSP00000305692 | ENSP00000340200 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | glycine-N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.725 |
| GAA | MPG | ENSP00000305692 | ENSP00000219431 | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | N-methylpurine-DNA glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions | 0.778 |
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