NMNAT3 protein (Homo sapiens) - STRING network view

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NMNAT3

nicotinamide nucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as subs [...] (215 aa)

Predicted Functional Partners:

NADSYN1

0.984

QPRT

0.955

NAMPTL

0.948

NAPRT1

0.948

NADK

0.948

NNT

0.941

NMRK2

0.919

NMRK1

0.908

BST1

0.900

NT5E

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BST1	NADK	ENSP00000265016	ENSP00000340925	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	NAD kinase	0.914
BST1	NADSYN1	ENSP00000265016	ENSP00000326424	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	NAD synthetase 1	0.900
BST1	NAMPTL	ENSP00000265016	ENSP00000407952	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	nicotinamide phosphoribosyltransferase-like	0.900
BST1	NMNAT3	ENSP00000265016	ENSP00000340523	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	nicotinamide nucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as subs [...]	0.900
BST1	NNT	ENSP00000265016	ENSP00000264663	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	nicotinamide nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland	0.900
BST1	QPRT	ENSP00000265016	ENSP00000378782	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.566
NADK	BST1	ENSP00000340925	ENSP00000265016	NAD kinase	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	0.914
NADK	NADSYN1	ENSP00000340925	ENSP00000326424	NAD kinase	NAD synthetase 1	0.900
NADK	NMNAT3	ENSP00000340925	ENSP00000340523	NAD kinase	nicotinamide nucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as subs [...]	0.948
NADK	NNT	ENSP00000340925	ENSP00000264663	NAD kinase	nicotinamide nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland	0.867
NADK	QPRT	ENSP00000340925	ENSP00000378782	NAD kinase	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.407
NADSYN1	BST1	ENSP00000326424	ENSP00000265016	NAD synthetase 1	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	0.900
NADSYN1	NADK	ENSP00000326424	ENSP00000340925	NAD synthetase 1	NAD kinase	0.900
NADSYN1	NAMPTL	ENSP00000326424	ENSP00000407952	NAD synthetase 1	nicotinamide phosphoribosyltransferase-like	0.838
NADSYN1	NAPRT1	ENSP00000326424	ENSP00000401508	NAD synthetase 1	nicotinate phosphoribosyltransferase domain containing 1; Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells	0.863
NADSYN1	NMNAT3	ENSP00000326424	ENSP00000340523	NAD synthetase 1	nicotinamide nucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as subs [...]	0.984
NADSYN1	NMRK2	ENSP00000326424	ENSP00000168977	NAD synthetase 1	nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis	0.450
NADSYN1	NNT	ENSP00000326424	ENSP00000264663	NAD synthetase 1	nicotinamide nucleotide transhydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland	0.957
NADSYN1	QPRT	ENSP00000326424	ENSP00000378782	NAD synthetase 1	quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA)	0.708
NAMPTL	BST1	ENSP00000407952	ENSP00000265016	nicotinamide phosphoribosyltransferase-like	bone marrow stromal cell antigen 1; Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth	0.900

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