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OBSCN OBSCN VAV1 VAV1 MCF2L MCF2L RHOT2 RHOT2 RHOBTB2 RHOBTB2 MCF2 MCF2 ABR ABR RHOA RHOA SYDE2 SYDE2 ARHGEF6 ARHGEF6 ARHGEF7 ARHGEF7
"SYDE2" - synapse defective 1, Rho GTPase, homolog 2 (C. elegans) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1194 aa)    
Predicted Functional Partners:
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7 (803 aa)
          score_image score_image   0.913
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) (776 aa)
          score_image score_image   0.913
ABR
active BCR-related (859 aa)
          score_image score_image score_image 0.901
RHOT2
ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa)
          score_image score_image   0.900
VAV1
vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation (845 aa)
          score_image     0.900
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (8678 aa)
          score_image     0.900
MCF2L
MCF.2 cell line derived transforming sequence-like (1125 aa)
          score_image     0.900
MCF2
MCF.2 cell line derived transforming sequence (1001 aa)
          score_image     0.900
RHOBTB2
Rho-related BTB domain containing 2 (749 aa)
          score_image     0.900
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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