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CYP2D6 CYP2D6 PNMT PNMT COMT COMT DBH DBH ADH7 ADH7 DDC DDC MAOA MAOA ALDH1B1 ALDH1B1 AANAT AANAT HNMT HNMT ADH1B ADH1B
"MAOA" - monoamine oxidase A in Homo sapiens
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Predicted Interactions
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MAOAmonoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (527 aa)    
Predicted Functional Partners:
COMT
catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (271 aa)
          score_image score_image   0.981
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase); Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine (480 aa)
      score_image   score_image score_image   0.957
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase); Conversion of dopamine to noradrenaline (617 aa)
          score_image score_image   0.948
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants (497 aa)
          score_image score_image   0.942
PNMT
phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline (282 aa)
          score_image score_image   0.938
ALDH1B1
aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)
          score_image score_image   0.927
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
          score_image score_image   0.925
AANAT
aralkylamine N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin (252 aa)
          score_image score_image   0.923
HNMT
histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (292 aa)
          score_image score_image   0.923
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa)
          score_image score_image   0.922
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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