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KIAA1644 KIAA1644 RPL34 RPL34 HUS1B HUS1B CLEC2A CLEC2A GJB5 GJB5 GJB4 GJB4 GJA4 GJA4 ARHGDIB ARHGDIB LY6E LY6E ABTB1 ABTB1 ATP1B2 ATP1B2
"GJB5" - gap junction protein, beta 5, 31.1kDa in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
GJB5gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (273 aa)    
Predicted Functional Partners:
CLEC2A
C-type lectin domain family 2, member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity (174 aa)
            score_image   0.681
LY6E
lymphocyte antigen 6 complex, locus E (131 aa)
            score_image   0.633
ABTB1
ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (478 aa)
            score_image   0.598
KIAA1644
KIAA1644 (199 aa)
            score_image   0.499
RPL34
ribosomal protein L34 (117 aa)
            score_image   0.489
GJB4
gap junction protein, beta 4, 30.3kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (266 aa)
      score_image   score_image score_image score_image 0.470
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (290 aa)
            score_image   0.469
HUS1B
HUS1 checkpoint homolog b (S. pombe) (278 aa)
            score_image   0.457
GJA4
gap junction protein, alpha 4, 37kDa (333 aa)
        score_image score_image score_image score_image 0.452
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (201 aa)
            score_image   0.432
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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