Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C1QTNF1 | C1q and tumor necrosis factor related protein 1 (281 aa) | ||||||||||||
Predicted Functional Partners:
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 | CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone (503 aa) |
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0.865 | ||||||||||
 | NR4A1 | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 (611 aa) |
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0.865 | ||||||||||
 | ARMC5 | armadillo repeat containing 5 (935 aa) |
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0.692 | ||||||||||
 | LRRC17 | leucine rich repeat containing 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity) (441 aa) |
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0.650 | ||||||||||
 | FAM132B | family with sequence similarity 132, member B; Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity) (354 aa) |
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0.646 | ||||||||||
 | MEGF6 | multiple EGF-like-domains 6 (1541 aa) |
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0.640 | ||||||||||
 | ENSG00000179253 | Novel protein (FLJ40547); Uncharacterized protein (140 aa) |
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0.454 | ||||||||||
 | FAM132A | family with sequence similarity 132, member A (302 aa) |
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0.450 | ||||||||||
 | ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae); Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (2120 aa) |
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0.440 | ||||||||||
 | C15orf60 | chromosome 15 open reading frame 60; May play a role in meiotic DNA double-strand break formation (By similarity) (266 aa) |
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0.414 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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