Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KLHL32 KLHL32 CSTF2 CSTF2 HSD11B2 HSD11B2 SPAG8 SPAG8 RAN RAN LEP LEP RANBP9 RANBP9 H6PD H6PD HSD17B6 HSD17B6 HSD17B1 HSD17B1 HSD11B1 HSD11B1
"SPAG8" - sperm associated antigen 8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPAG8sperm associated antigen 8; May play a role in fertility and microtubule formation through interaction with RANBP9 (501 aa)    
Predicted Functional Partners:
LEP
leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass (167 aa)
             score_image   0.863
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2 (405 aa)
             score_image   0.824
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity) (292 aa)
             score_image   0.703
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] (317 aa)
             score_image   0.659
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates (791 aa)
             score_image   0.650
RANBP9
RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] (729 aa)
         score_image   score_image   0.648
RAN
RAN, member RAS oncogene family (216 aa)
         score_image       0.576
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH (328 aa)
             score_image   0.537
KLHL32
kelch-like 32 (Drosophila) (620 aa)
         score_image       0.537
CSTF2
cleavage stimulation factor, 3’ pre-RNA, subunit 2, 64kDa; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) (577 aa)
         score_image       0.524
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (42%)