NPR2 protein (Homo sapiens) - STRING network view

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NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (1047 aa)

Predicted Functional Partners:

NPPC

0.990

NPPA

0.973

NPPB

0.966

PDE5A

0.964

PDE2A

0.956

PDE11A

0.956

PDE10A

0.955

PDE6B

0.955

PDE6C

0.955

PDE9A

0.955

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NPPA	NPPB	ENSP00000365663	ENSP00000365651	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.946
NPPA	NPPC	ENSP00000365663	ENSP00000295440	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.537
NPPA	NPR2	ENSP00000365663	ENSP00000341083	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	0.973
NPPA	PDE5A	ENSP00000365663	ENSP00000347046	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP	0.529
NPPB	NPPA	ENSP00000365651	ENSP00000365663	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.946
NPPB	NPPC	ENSP00000365651	ENSP00000295440	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.583
NPPB	NPR2	ENSP00000365651	ENSP00000341083	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	0.966
NPPC	NPPA	ENSP00000295440	ENSP00000365663	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.537
NPPC	NPPB	ENSP00000295440	ENSP00000365651	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.583
NPPC	NPR2	ENSP00000295440	ENSP00000341083	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	0.990
NPR2	NPPA	ENSP00000341083	ENSP00000365663	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.973
NPR2	NPPB	ENSP00000341083	ENSP00000365651	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	natriuretic peptide B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.966
NPR2	NPPC	ENSP00000341083	ENSP00000295440	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.990
NPR2	PDE10A	ENSP00000341083	ENSP00000438284	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate	0.955
NPR2	PDE11A	ENSP00000341083	ENSP00000286063	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5’-AMP and 5’- GMP, respectively	0.956
NPR2	PDE2A	ENSP00000341083	ENSP00000334910	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes	0.956
NPR2	PDE5A	ENSP00000341083	ENSP00000347046	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP	0.964
NPR2	PDE6B	ENSP00000341083	ENSP00000420295	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme	0.955
NPR2	PDE6C	ENSP00000341083	ENSP00000360502	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	0.955
NPR2	PDE9A	ENSP00000341083	ENSP00000291539	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	phosphodiesterase 9A	0.955

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