CLUL1 protein (Homo sapiens) - STRING network view

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Score

CLUL1

clusterin-like 1 (retinal) (466 aa)

Predicted Functional Partners:

XRCC6

0.576

EEA1

0.576

MYL12A

0.565

LPIN2

0.560

METTL4

0.510

MYOM1

0.509

MYL12B

0.507

ZFP161

0.474

TMEM51

0.472

DLGAP1

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLUL1	DLGAP1	ENSP00000341128	ENSP00000316377	clusterin-like 1 (retinal)	discs, large (Drosophila) homolog-associated protein 1	0.416
CLUL1	EEA1	ENSP00000341128	ENSP00000317955	clusterin-like 1 (retinal)	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	0.576
CLUL1	LPIN2	ENSP00000341128	ENSP00000261596	clusterin-like 1 (retinal)	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	0.560
CLUL1	METTL4	ENSP00000341128	ENSP00000458290	clusterin-like 1 (retinal)	methyltransferase like 4; Probable methyltransferase (By similarity)	0.510
CLUL1	MYL12A	ENSP00000341128	ENSP00000217652	clusterin-like 1 (retinal)	myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)	0.565
CLUL1	MYL12B	ENSP00000341128	ENSP00000237500	clusterin-like 1 (retinal)	myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)	0.507
CLUL1	MYOM1	ENSP00000341128	ENSP00000348821	clusterin-like 1 (retinal)	myomesin 1; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent	0.509
CLUL1	TMEM51	ENSP00000341128	ENSP00000365176	clusterin-like 1 (retinal)	transmembrane protein 51	0.472
CLUL1	XRCC6	ENSP00000341128	ENSP00000352257	clusterin-like 1 (retinal)	X-ray repair complementing defective repair in Chinese hamster cells 6; Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3’-5’ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the [...]	0.576
CLUL1	ZFP161	ENSP00000341128	ENSP00000349503	clusterin-like 1 (retinal)	zinc finger protein 161 homolog (mouse); Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters	0.474
DLGAP1	CLUL1	ENSP00000316377	ENSP00000341128	discs, large (Drosophila) homolog-associated protein 1	clusterin-like 1 (retinal)	0.416
DLGAP1	METTL4	ENSP00000316377	ENSP00000458290	discs, large (Drosophila) homolog-associated protein 1	methyltransferase like 4; Probable methyltransferase (By similarity)	0.418
EEA1	CLUL1	ENSP00000317955	ENSP00000341128	early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking	clusterin-like 1 (retinal)	0.576
LPIN2	CLUL1	ENSP00000261596	ENSP00000341128	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	clusterin-like 1 (retinal)	0.560
LPIN2	METTL4	ENSP00000261596	ENSP00000458290	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	methyltransferase like 4; Probable methyltransferase (By similarity)	0.476
LPIN2	MYOM1	ENSP00000261596	ENSP00000348821	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	myomesin 1; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent	0.412
LPIN2	ZFP161	ENSP00000261596	ENSP00000349503	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	zinc finger protein 161 homolog (mouse); Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters	0.759
METTL4	CLUL1	ENSP00000458290	ENSP00000341128	methyltransferase like 4; Probable methyltransferase (By similarity)	clusterin-like 1 (retinal)	0.510
METTL4	DLGAP1	ENSP00000458290	ENSP00000316377	methyltransferase like 4; Probable methyltransferase (By similarity)	discs, large (Drosophila) homolog-associated protein 1	0.418
METTL4	LPIN2	ENSP00000458290	ENSP00000261596	methyltransferase like 4; Probable methyltransferase (By similarity)	lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity)	0.476

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