RNF13 protein (Homo sapiens) - STRING network view

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RNF13

ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation (381 aa)

Predicted Functional Partners:

SNAPIN

0.924

UBC

0.802

UBE2D1

0.655

LAMP2

0.630

SIPA1

0.612

ZBTB32

0.586

ERN1

0.576

LMNB1

0.576

CD63

0.576

PGRMC1

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD63	LAMP2	ENSP00000257857	ENSP00000408411	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens	0.831
CD63	RNF13	ENSP00000257857	ENSP00000341361	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	0.576
CD63	UBC	ENSP00000257857	ENSP00000344818	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	ubiquitin C	0.909
ERN1	RNF13	ENSP00000401445	ENSP00000341361	endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	0.576
ERN1	UBC	ENSP00000401445	ENSP00000344818	endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis	ubiquitin C	0.844
LAMP2	CD63	ENSP00000408411	ENSP00000257857	lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	0.831
LAMP2	RNF13	ENSP00000408411	ENSP00000341361	lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	0.630
LMNB1	RNF13	ENSP00000261366	ENSP00000341361	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	0.576
LMNB1	UBC	ENSP00000261366	ENSP00000344818	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	ubiquitin C	0.971
PGRMC1	RNF13	ENSP00000217971	ENSP00000341361	progesterone receptor membrane component 1; Receptor for progesterone (By similarity)	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	0.576
PGRMC1	UBC	ENSP00000217971	ENSP00000344818	progesterone receptor membrane component 1; Receptor for progesterone (By similarity)	ubiquitin C	0.861
RNF13	CD63	ENSP00000341361	ENSP00000257857	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation	0.576
RNF13	ERN1	ENSP00000341361	ENSP00000401445	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	endoplasmic reticulum to nucleus signaling 1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis	0.576
RNF13	LAMP2	ENSP00000341361	ENSP00000408411	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens	0.630
RNF13	LMNB1	ENSP00000341361	ENSP00000261366	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.576
RNF13	PGRMC1	ENSP00000341361	ENSP00000217971	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	progesterone receptor membrane component 1; Receptor for progesterone (By similarity)	0.576
RNF13	SIPA1	ENSP00000341361	ENSP00000377771	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	signal-induced proliferation-associated 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state	0.612
RNF13	SNAPIN	ENSP00000341361	ENSP00000357674	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	SNAP-associated protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May modulate a step between vesicle priming, fusion [...]	0.924
RNF13	UBC	ENSP00000341361	ENSP00000344818	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	ubiquitin C	0.802
RNF13	UBE2D1	ENSP00000341361	ENSP00000363019	ring finger protein 13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation	ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...]	0.655

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