Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABR | ARHGEF4 | ENSP00000303909 | ENSP00000316845 | active BCR-related | Rho guanine nucleotide exchange factor (GEF) 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression | 0.900 |
ABR | ARHGEF6 | ENSP00000303909 | ENSP00000250617 | active BCR-related | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | 0.915 |
ABR | ARHGEF7 | ENSP00000303909 | ENSP00000364893 | active BCR-related | Rho guanine nucleotide exchange factor (GEF) 7 | 0.915 |
ABR | FGD1 | ENSP00000303909 | ENSP00000364277 | active BCR-related | FYVE, RhoGEF and PH domain containing 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape | 0.908 |
ABR | MCF2 | ENSP00000303909 | ENSP00000430276 | active BCR-related | MCF.2 cell line derived transforming sequence | 0.940 |
ABR | MCF2L | ENSP00000303909 | ENSP00000440374 | active BCR-related | MCF.2 cell line derived transforming sequence-like | 0.907 |
ABR | OBSCN | ENSP00000303909 | ENSP00000455507 | active BCR-related | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.900 |
ABR | SYDE1 | ENSP00000303909 | ENSP00000341489 | active BCR-related | synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | 0.901 |
ABR | TIAM1 | ENSP00000303909 | ENSP00000286827 | active BCR-related | T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA | 0.922 |
ABR | VAV1 | ENSP00000303909 | ENSP00000472929 | active BCR-related | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.935 |
ARHGEF4 | ABR | ENSP00000316845 | ENSP00000303909 | Rho guanine nucleotide exchange factor (GEF) 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression | active BCR-related | 0.900 |
ARHGEF4 | SYDE1 | ENSP00000316845 | ENSP00000341489 | Rho guanine nucleotide exchange factor (GEF) 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression | synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | 0.900 |
ARHGEF6 | ABR | ENSP00000250617 | ENSP00000303909 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | active BCR-related | 0.915 |
ARHGEF6 | ARHGEF7 | ENSP00000250617 | ENSP00000364893 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | Rho guanine nucleotide exchange factor (GEF) 7 | 0.980 |
ARHGEF6 | SYDE1 | ENSP00000250617 | ENSP00000341489 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | 0.940 |
ARHGEF7 | ABR | ENSP00000364893 | ENSP00000303909 | Rho guanine nucleotide exchange factor (GEF) 7 | active BCR-related | 0.915 |
ARHGEF7 | ARHGEF6 | ENSP00000364893 | ENSP00000250617 | Rho guanine nucleotide exchange factor (GEF) 7 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF) | 0.980 |
ARHGEF7 | SYDE1 | ENSP00000364893 | ENSP00000341489 | Rho guanine nucleotide exchange factor (GEF) 7 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) | 0.913 |
FGD1 | ABR | ENSP00000364277 | ENSP00000303909 | FYVE, RhoGEF and PH domain containing 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape | active BCR-related | 0.908 |
FGD1 | MCF2 | ENSP00000364277 | ENSP00000430276 | FYVE, RhoGEF and PH domain containing 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape | MCF.2 cell line derived transforming sequence | 0.563 |
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