DCAKD protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DCAKD

dephospho-CoA kinase domain containing (231 aa)

Predicted Functional Partners:

UBC

0.948

PPCDC

0.674

CDC6

0.672

MTHFD1

0.645

MTHFD1L

0.645

PANK4

0.604

PANK2

0.589

PANK1

0.589

PANK3

0.589

PPCS

0.586

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC6	DCAKD	ENSP00000209728	ENSP00000341504	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	dephospho-CoA kinase domain containing	0.672
CDC6	UBC	ENSP00000209728	ENSP00000344818	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	ubiquitin C	0.991
DCAKD	CDC6	ENSP00000341504	ENSP00000209728	dephospho-CoA kinase domain containing	cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated	0.672
DCAKD	MTHFD1	ENSP00000341504	ENSP00000450560	dephospho-CoA kinase domain containing	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.645
DCAKD	MTHFD1L	ENSP00000341504	ENSP00000356290	dephospho-CoA kinase domain containing	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.645
DCAKD	PANK1	ENSP00000341504	ENSP00000302108	dephospho-CoA kinase domain containing	pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity)	0.589
DCAKD	PANK2	ENSP00000341504	ENSP00000313377	dephospho-CoA kinase domain containing	pantothenate kinase 2	0.589
DCAKD	PANK3	ENSP00000341504	ENSP00000239231	dephospho-CoA kinase domain containing	pantothenate kinase 3; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity)	0.589
DCAKD	PANK4	ENSP00000341504	ENSP00000367727	dephospho-CoA kinase domain containing	pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity)	0.604
DCAKD	PPCDC	ENSP00000341504	ENSP00000343190	dephospho-CoA kinase domain containing	phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine	0.674
DCAKD	PPCS	ENSP00000341504	ENSP00000361642	dephospho-CoA kinase domain containing	phosphopantothenoylcysteine synthetase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine	0.586
DCAKD	UBC	ENSP00000341504	ENSP00000344818	dephospho-CoA kinase domain containing	ubiquitin C	0.948
MTHFD1	DCAKD	ENSP00000450560	ENSP00000341504	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	dephospho-CoA kinase domain containing	0.645
MTHFD1	MTHFD1L	ENSP00000450560	ENSP00000356290	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.977
MTHFD1	UBC	ENSP00000450560	ENSP00000344818	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	ubiquitin C	0.975
MTHFD1L	DCAKD	ENSP00000356290	ENSP00000341504	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	dephospho-CoA kinase domain containing	0.645
MTHFD1L	MTHFD1	ENSP00000356290	ENSP00000450560	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.977
MTHFD1L	UBC	ENSP00000356290	ENSP00000344818	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	ubiquitin C	0.578
PANK1	DCAKD	ENSP00000302108	ENSP00000341504	pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity)	dephospho-CoA kinase domain containing	0.589
PANK1	PPCDC	ENSP00000302108	ENSP00000343190	pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity)	phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine	0.819

page 1 of 3

Experiments

Neighborhood

Databases

Cooccurrence

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About