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SOCS7 SOCS7 IFNGR1 IFNGR1 SEPT5 SEPT5 SEPT2 SEPT2 SEPT6 SEPT6 SEPT1 SEPT1 UBC UBC HNRNPA1 HNRNPA1 SEPT7 SEPT7 SEPT12 SEPT12 MAP4 MAP4
"SEPT6" - septin 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
SEPT6septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication (434 aa)    
Predicted Functional Partners:
SEPT2
septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] (361 aa)
      score_image score_image score_image score_image score_image 0.999
SEPT5
septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) (369 aa)
      score_image score_image score_image score_image score_image 0.988
SEPT7
septin 7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements (438 aa)
      score_image score_image score_image score_image score_image 0.987
SEPT1
septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (367 aa)
      score_image score_image score_image score_image score_image 0.972
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication (372 aa)
      score_image score_image   score_image   0.951
SOCS7
suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of t [...] (581 aa)
        score_image   score_image   0.892
MAP4
microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly (1152 aa)
            score_image   0.851
SEPT12
septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (358 aa)
        score_image score_image score_image score_image 0.840
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.840
IFNGR1
interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer (489 aa)
        score_image   score_image   0.812
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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