node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HNRNPA1 | SEPT6 | ENSP00000341826 | ENSP00000341524 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.951 |
HNRNPA1 | UBC | ENSP00000341826 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication | ubiquitin C | 0.998 |
IFNGR1 | SEPT6 | ENSP00000356713 | ENSP00000341524 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.812 |
IFNGR1 | SOCS7 | ENSP00000356713 | ENSP00000464034 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of t [...] | 0.800 |
IFNGR1 | UBC | ENSP00000356713 | ENSP00000344818 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | ubiquitin C | 0.941 |
MAP4 | SEPT6 | ENSP00000353375 | ENSP00000341524 | microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.851 |
MAP4 | SEPT7 | ENSP00000353375 | ENSP00000381992 | microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly | septin 7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements | 0.405 |
MAP4 | UBC | ENSP00000353375 | ENSP00000344818 | microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly | ubiquitin C | 0.923 |
SEPT1 | SEPT12 | ENSP00000460441 | ENSP00000268231 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.848 |
SEPT1 | SEPT2 | ENSP00000460441 | ENSP00000353157 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.800 |
SEPT1 | SEPT5 | ENSP00000460441 | ENSP00000391311 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.919 |
SEPT1 | SEPT6 | ENSP00000460441 | ENSP00000341524 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.972 |
SEPT1 | UBC | ENSP00000460441 | ENSP00000344818 | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | ubiquitin C | 0.784 |
SEPT12 | SEPT1 | ENSP00000268231 | ENSP00000460441 | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.848 |
SEPT12 | SEPT2 | ENSP00000268231 | ENSP00000353157 | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.621 |
SEPT12 | SEPT5 | ENSP00000268231 | ENSP00000391311 | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity) | 0.625 |
SEPT12 | SEPT6 | ENSP00000268231 | ENSP00000341524 | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication | 0.840 |
SEPT12 | SEPT7 | ENSP00000268231 | ENSP00000381992 | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements | 0.620 |
SEPT2 | SEPT1 | ENSP00000353157 | ENSP00000460441 | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | septin 1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.800 |
SEPT2 | SEPT12 | ENSP00000353157 | ENSP00000268231 | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | septin 12; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | 0.621 |