node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGMO | ALDH3A2 | ENSP00000341662 | ENSP00000345774 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.864 |
AGMO | C14orf1 | ENSP00000341662 | ENSP00000256319 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | chromosome 14 open reading frame 1 | 0.889 |
AGMO | C5orf4 | ENSP00000341662 | ENSP00000320604 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | chromosome 5 open reading frame 4 | 0.912 |
AGMO | CH25H | ENSP00000341662 | ENSP00000360918 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.899 |
AGMO | DHCR7 | ENSP00000341662 | ENSP00000347717 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.852 |
AGMO | FA2H | ENSP00000341662 | ENSP00000219368 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.868 |
AGMO | FDFT1 | ENSP00000341662 | ENSP00000220584 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | farnesyl-diphosphate farnesyltransferase 1 | 0.922 |
AGMO | LBR | ENSP00000341662 | ENSP00000272163 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.852 |
AGMO | MSMO1 | ENSP00000341662 | ENSP00000261507 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | methylsterol monooxygenase 1 | 0.898 |
AGMO | TM7SF2 | ENSP00000341662 | ENSP00000279263 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol | 0.852 |
ALDH3A2 | AGMO | ENSP00000345774 | ENSP00000341662 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.864 |
ALDH3A2 | FA2H | ENSP00000345774 | ENSP00000219368 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.410 |
C14orf1 | AGMO | ENSP00000256319 | ENSP00000341662 | chromosome 14 open reading frame 1 | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes | 0.889 |
C14orf1 | C5orf4 | ENSP00000256319 | ENSP00000320604 | chromosome 14 open reading frame 1 | chromosome 5 open reading frame 4 | 0.859 |
C14orf1 | CH25H | ENSP00000256319 | ENSP00000360918 | chromosome 14 open reading frame 1 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.858 |
C14orf1 | DHCR7 | ENSP00000256319 | ENSP00000347717 | chromosome 14 open reading frame 1 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) | 0.802 |
C14orf1 | FA2H | ENSP00000256319 | ENSP00000219368 | chromosome 14 open reading frame 1 | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.450 |
C14orf1 | FDFT1 | ENSP00000256319 | ENSP00000220584 | chromosome 14 open reading frame 1 | farnesyl-diphosphate farnesyltransferase 1 | 0.956 |
C14orf1 | LBR | ENSP00000256319 | ENSP00000272163 | chromosome 14 open reading frame 1 | lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane | 0.789 |
C14orf1 | MSMO1 | ENSP00000256319 | ENSP00000261507 | chromosome 14 open reading frame 1 | methylsterol monooxygenase 1 | 0.916 |