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KPNA6 KPNA6 BTN3A1 BTN3A1 SMURF1 SMURF1 FOXP1 FOXP1 KPNA7 KPNA7 IL1F10 IL1F10 OR2A25 OR2A25 IL36B IL36B IL1R1 IL1R1 IL1A IL1A IL1RL2 IL1RL2
"IL1F10" - interleukin 1 family, member 10 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
IL1F10interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 (152 aa)    
Predicted Functional Partners:
KPNA7
karyopherin alpha 7 (importin alpha 8); Functions in nuclear protein import (By similarity) (516 aa)
            score_image   0.862
BTN3A1
butyrophilin, subfamily 3, member A1 (513 aa)
            score_image   0.860
KPNA6
karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] (536 aa)
            score_image   0.756
FOXP1
forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) (677 aa)
            score_image   0.728
IL36B
interleukin 36, beta; Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases (164 aa)
            score_image   0.722
IL1R1
interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (569 aa)
        score_image   score_image   0.674
SMURF1
SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (757 aa)
            score_image   0.608
IL1A
interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (271 aa)
            score_image   0.503
OR2A25
olfactory receptor, family 2, subfamily A, member 25; Odorant receptor (Potential) (310 aa)
            score_image   0.501
IL1RL2
interleukin 1 receptor-like 2; Receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B (575 aa)
            score_image   0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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