node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTN3A1 | FOXP1 | ENSP00000289361 | ENSP00000318902 | butyrophilin, subfamily 3, member A1 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | 0.681 |
BTN3A1 | IL1F10 | ENSP00000289361 | ENSP00000341794 | butyrophilin, subfamily 3, member A1 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | 0.860 |
BTN3A1 | KPNA6 | ENSP00000289361 | ENSP00000362728 | butyrophilin, subfamily 3, member A1 | karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | 0.751 |
BTN3A1 | KPNA7 | ENSP00000289361 | ENSP00000330878 | butyrophilin, subfamily 3, member A1 | karyopherin alpha 7 (importin alpha 8); Functions in nuclear protein import (By similarity) | 0.860 |
BTN3A1 | SMURF1 | ENSP00000289361 | ENSP00000354621 | butyrophilin, subfamily 3, member A1 | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.581 |
FOXP1 | BTN3A1 | ENSP00000318902 | ENSP00000289361 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | butyrophilin, subfamily 3, member A1 | 0.681 |
FOXP1 | IL1F10 | ENSP00000318902 | ENSP00000341794 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | 0.728 |
FOXP1 | KPNA6 | ENSP00000318902 | ENSP00000362728 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | 0.512 |
FOXP1 | KPNA7 | ENSP00000318902 | ENSP00000330878 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | karyopherin alpha 7 (importin alpha 8); Functions in nuclear protein import (By similarity) | 0.742 |
IL1A | IL1F10 | ENSP00000263339 | ENSP00000341794 | interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | 0.503 |
IL1A | IL1R1 | ENSP00000263339 | ENSP00000233946 | interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | 0.992 |
IL1A | IL1RL2 | ENSP00000263339 | ENSP00000264257 | interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | interleukin 1 receptor-like 2; Receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B | 0.438 |
IL1A | IL36B | ENSP00000263339 | ENSP00000259213 | interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | interleukin 36, beta; Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases | 0.471 |
IL1F10 | BTN3A1 | ENSP00000341794 | ENSP00000289361 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | butyrophilin, subfamily 3, member A1 | 0.860 |
IL1F10 | FOXP1 | ENSP00000341794 | ENSP00000318902 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | 0.728 |
IL1F10 | IL1A | ENSP00000341794 | ENSP00000263339 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | interleukin 1, alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells | 0.503 |
IL1F10 | IL1R1 | ENSP00000341794 | ENSP00000233946 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | interleukin 1 receptor, type I; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex | 0.674 |
IL1F10 | IL1RL2 | ENSP00000341794 | ENSP00000264257 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | interleukin 1 receptor-like 2; Receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B | 0.499 |
IL1F10 | IL36B | ENSP00000341794 | ENSP00000259213 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | interleukin 36, beta; Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases | 0.722 |
IL1F10 | KPNA6 | ENSP00000341794 | ENSP00000362728 | interleukin 1 family, member 10 (theta); Binds soluble IL-1 receptor type 1 | karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | 0.756 |