Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
BMP2 BMP2 NOG NOG BMP6 BMP6 VWC2 VWC2 GDF5 GDF5 CHRD CHRD VWF VWF
"VWC2" - von Willebrand factor C domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VWC2von Willebrand factor C domain containing 2; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity) (325 aa)    
Predicted Functional Partners:
CHRD
chordin (955 aa)
             score_image   0.658
BMP6
bone morphogenetic protein 6; Induces cartilage and bone formation (513 aa)
             score_image   0.564
VWF
von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (2813 aa)
             score_image   0.489
NOG
noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (232 aa)
             score_image   0.482
GDF5
growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B (501 aa)
             score_image   0.439
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
             score_image   0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (45%)