node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA1 | APP | ENSP00000257497 | ENSP00000284981 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | amyloid beta (A4) precursor protein | 0.925 |
ANXA1 | DRD4 | ENSP00000257497 | ENSP00000176183 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | dopamine receptor D4 | 0.900 |
ANXA1 | FPR3 | ENSP00000257497 | ENSP00000341821 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system | 0.943 |
ANXA1 | HEBP1 | ENSP00000257497 | ENSP00000014930 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | heme binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities | 0.900 |
ANXA1 | HTR1E | ENSP00000257497 | ENSP00000307766 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.900 |
ANXA1 | IL8 | ENSP00000257497 | ENSP00000306512 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | interleukin 8 | 0.916 |
ANXA1 | RGS1 | ENSP00000257497 | ENSP00000356429 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | regulator of G-protein signaling 1; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation | 0.900 |
ANXA1 | TAS2R16 | ENSP00000257497 | ENSP00000249284 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | taste receptor, type 2, member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 | 0.900 |
ANXA1 | TAS2R4 | ENSP00000257497 | ENSP00000247881 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | taste receptor, type 2, member 4; Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency | 0.900 |
APP | ANXA1 | ENSP00000284981 | ENSP00000257497 | amyloid beta (A4) precursor protein | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | 0.925 |
APP | DRD4 | ENSP00000284981 | ENSP00000176183 | amyloid beta (A4) precursor protein | dopamine receptor D4 | 0.900 |
APP | FPR3 | ENSP00000284981 | ENSP00000341821 | amyloid beta (A4) precursor protein | formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system | 0.916 |
APP | HEBP1 | ENSP00000284981 | ENSP00000014930 | amyloid beta (A4) precursor protein | heme binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities | 0.900 |
APP | HTR1E | ENSP00000284981 | ENSP00000307766 | amyloid beta (A4) precursor protein | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.900 |
APP | IL8 | ENSP00000284981 | ENSP00000306512 | amyloid beta (A4) precursor protein | interleukin 8 | 0.916 |
APP | RGS1 | ENSP00000284981 | ENSP00000356429 | amyloid beta (A4) precursor protein | regulator of G-protein signaling 1; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation | 0.901 |
APP | TAS2R16 | ENSP00000284981 | ENSP00000249284 | amyloid beta (A4) precursor protein | taste receptor, type 2, member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 | 0.900 |
APP | TAS2R4 | ENSP00000284981 | ENSP00000247881 | amyloid beta (A4) precursor protein | taste receptor, type 2, member 4; Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency | 0.900 |
DRD4 | ANXA1 | ENSP00000176183 | ENSP00000257497 | dopamine receptor D4 | annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity | 0.900 |
DRD4 | APP | ENSP00000176183 | ENSP00000284981 | dopamine receptor D4 | amyloid beta (A4) precursor protein | 0.900 |