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STRINGSTRING
HPN HPN HGF HGF HGFAC HGFAC ST14 ST14 TMPRSS11F TMPRSS11F TMPRSS4 TMPRSS4 SPINT1 SPINT1 TMPRSS11A TMPRSS11A KLK4 KLK4 PRSS8 PRSS8 TMPRSS11E TMPRSS11E
"SPINT1" - serine peptidase inhibitor, Kunitz type 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SPINT1serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) (529 aa)    
Predicted Functional Partners:
HGFAC
HGF activator; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form (655 aa)
         score_image   score_image   0.998
ST14
suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (855 aa)
       score_image score_image   score_image   0.998
PRSS8
protease, serine, 8; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) (343 aa)
             score_image   0.937
HGF
hepatocyte growth factor (hepapoietin A; scatter factor) (728 aa)
       score_image     score_image   0.753
HPN
hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL (417 aa)
             score_image   0.636
TMPRSS4
transmembrane protease, serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity) (437 aa)
             score_image   0.618
KLK4
kallikrein-related peptidase 4; Involved in enamel formation (254 aa)
             score_image   0.607
TMPRSS11E
transmembrane protease, serine 11E; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity) (423 aa)
             score_image   0.593
TMPRSS11A
transmembrane protease, serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest (421 aa)
             score_image   0.565
TMPRSS11F
transmembrane protease, serine 11F; Probable serine protease (By similarity) (438 aa)
             score_image   0.485
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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