| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | RNF6 | ENSP00000363822 | ENSP00000342121 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.926 |
| ATP8A2 | DLEC1 | ENSP00000371070 | ENSP00000308597 | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | 0.407 |
| ATP8A2 | RNF6 | ENSP00000371070 | ENSP00000342121 | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.816 |
| ATP8A2 | S100A14 | ENSP00000371070 | ENSP00000340463 | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | S100 calcium binding protein A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium | 0.414 |
| DLEC1 | ATP8A2 | ENSP00000308597 | ENSP00000371070 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | 0.407 |
| DLEC1 | LZTS1 | ENSP00000308597 | ENSP00000265801 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor | 0.680 |
| DLEC1 | RNF6 | ENSP00000308597 | ENSP00000342121 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.681 |
| DLEC1 | S100A14 | ENSP00000308597 | ENSP00000340463 | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | S100 calcium binding protein A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium | 0.680 |
| LDB1 | RNF6 | ENSP00000392466 | ENSP00000342121 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.852 |
| LDB2 | RNF6 | ENSP00000306772 | ENSP00000342121 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.659 |
| LZTS1 | DLEC1 | ENSP00000265801 | ENSP00000308597 | leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | 0.680 |
| LZTS1 | RNF6 | ENSP00000265801 | ENSP00000342121 | leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.680 |
| LZTS1 | S100A14 | ENSP00000265801 | ENSP00000340463 | leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor | S100 calcium binding protein A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium | 0.665 |
| PCGF6 | RNF6 | ENSP00000358862 | ENSP00000342121 | polycomb group ring finger 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | 0.754 |
| RNF6 | AR | ENSP00000342121 | ENSP00000363822 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.926 |
| RNF6 | ATP8A2 | ENSP00000342121 | ENSP00000371070 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | ATPase, aminophospholipid transporter, class I, type 8A, member 2 | 0.816 |
| RNF6 | DLEC1 | ENSP00000342121 | ENSP00000308597 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | deleted in lung and esophageal cancer 1; May act as a tumor suppressor by inhibiting cell proliferation | 0.681 |
| RNF6 | LDB1 | ENSP00000342121 | ENSP00000392466 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.852 |
| RNF6 | LDB2 | ENSP00000342121 | ENSP00000306772 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.659 |
| RNF6 | LZTS1 | ENSP00000342121 | ENSP00000265801 | ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator | leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor | 0.680 |
Share
