node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HLA-C | KIR2DL3 | ENSP00000365402 | ENSP00000342215 | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | 0.982 |
KIR2DL3 | HLA-C | ENSP00000342215 | ENSP00000365402 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) | 0.982 |
KIR2DL3 | LCK | ENSP00000342215 | ENSP00000337825 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | lymphocyte-specific protein tyrosine kinase | 0.576 |
KIR2DL3 | PTPN11 | ENSP00000342215 | ENSP00000340944 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.911 |
KIR2DL3 | PTPN6 | ENSP00000342215 | ENSP00000391592 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | 0.564 |
LCK | KIR2DL3 | ENSP00000337825 | ENSP00000342215 | lymphocyte-specific protein tyrosine kinase | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | 0.576 |
LCK | PTPN11 | ENSP00000337825 | ENSP00000340944 | lymphocyte-specific protein tyrosine kinase | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.972 |
LCK | PTPN6 | ENSP00000337825 | ENSP00000391592 | lymphocyte-specific protein tyrosine kinase | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | 0.719 |
PTPN11 | KIR2DL3 | ENSP00000340944 | ENSP00000342215 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | 0.911 |
PTPN11 | LCK | ENSP00000340944 | ENSP00000337825 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | lymphocyte-specific protein tyrosine kinase | 0.972 |
PTPN11 | PTPN6 | ENSP00000340944 | ENSP00000391592 | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | 0.582 |
PTPN6 | KIR2DL3 | ENSP00000391592 | ENSP00000342215 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis | 0.564 |
PTPN6 | LCK | ENSP00000391592 | ENSP00000337825 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | lymphocyte-specific protein tyrosine kinase | 0.719 |
PTPN6 | PTPN11 | ENSP00000391592 | ENSP00000340944 | protein tyrosine phosphatase, non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.582 |