Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix (301 aa) | ||||||||||||
Predicted Functional Partners:
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 | ASS1 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa) |
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0.961 | ||||||||
 | OTC | ornithine carbamoyltransferase (354 aa) |
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0.915 | ||||||||
 | ARG1 | arginase, liver (322 aa) |
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0.906 | |||||||||
 | ASL | argininosuccinate lyase (464 aa) |
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0.679 | |||||||||
 | OAT | ornithine aminotransferase (439 aa) |
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0.624 | ||||||||||
 | OGG1 | 8-oxoguanine DNA glycosylase (424 aa) |
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0.534 | ||||||||||
 | ENSG00000249319 | Uncharacterized protein (293 aa) |
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0.516 | ||||||||||
 | GJB2 | gap junction protein, beta 2, 26kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity) (226 aa) |
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0.508 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.483 | ||||||||||
 | LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (322 aa) |
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0.477 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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