| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BANF1 | UBC | ENSP00000310275 | ENSP00000344818 | barrier to autointegration factor 1; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Associat [...] | ubiquitin C | 0.860 |
| BANF1 | VRK2 | ENSP00000310275 | ENSP00000342381 | barrier to autointegration factor 1; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self- destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Associat [...] | vaccinia related kinase 2 | 0.943 |
| BDKRB1 | MAPK8IP1 | ENSP00000216629 | ENSP00000241014 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.814 |
| BDKRB1 | VRK2 | ENSP00000216629 | ENSP00000342381 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | vaccinia related kinase 2 | 0.790 |
| F10 | VRK2 | ENSP00000364709 | ENSP00000342381 | coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting | vaccinia related kinase 2 | 0.752 |
| KSR1 | MAP2K1 | ENSP00000323178 | ENSP00000302486 | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | 0.999 |
| KSR1 | VRK2 | ENSP00000323178 | ENSP00000342381 | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | vaccinia related kinase 2 | 0.836 |
| MAP2K1 | KSR1 | ENSP00000302486 | ENSP00000323178 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.999 |
| MAP2K1 | MAP3K7 | ENSP00000302486 | ENSP00000358335 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | mitogen-activated protein kinase kinase kinase 7 | 0.930 |
| MAP2K1 | UBC | ENSP00000302486 | ENSP00000344818 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | ubiquitin C | 0.943 |
| MAP2K1 | VRK2 | ENSP00000302486 | ENSP00000342381 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | vaccinia related kinase 2 | 0.836 |
| MAP3K7 | MAP2K1 | ENSP00000358335 | ENSP00000302486 | mitogen-activated protein kinase kinase kinase 7 | mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] | 0.930 |
| MAP3K7 | MAPK8IP1 | ENSP00000358335 | ENSP00000241014 | mitogen-activated protein kinase kinase kinase 7 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.918 |
| MAP3K7 | UBC | ENSP00000358335 | ENSP00000344818 | mitogen-activated protein kinase kinase kinase 7 | ubiquitin C | 0.999 |
| MAP3K7 | VRK2 | ENSP00000358335 | ENSP00000342381 | mitogen-activated protein kinase kinase kinase 7 | vaccinia related kinase 2 | 0.840 |
| MAPK8IP1 | BDKRB1 | ENSP00000241014 | ENSP00000216629 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.814 |
| MAPK8IP1 | MAP3K7 | ENSP00000241014 | ENSP00000358335 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | mitogen-activated protein kinase kinase kinase 7 | 0.918 |
| MAPK8IP1 | VRK2 | ENSP00000241014 | ENSP00000342381 | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | vaccinia related kinase 2 | 0.931 |
| RIOK2 | RPS3 | ENSP00000283109 | ENSP00000433821 | RIO kinase 2 (yeast) | ribosomal protein S3 | 0.637 |
| RIOK2 | UBC | ENSP00000283109 | ENSP00000344818 | RIO kinase 2 (yeast) | ubiquitin C | 0.805 |
Share
